Long-Term Treatment with Finasteride Induces Apoptosis and Pathological Changes in Female Mice

April 2019 in “ Human & Experimental Toxicology ”

Abdullah A. Alkahtane, Gadah Albasher, Nouf Alsultan, Wedad Saeed Al-Qahtani, Saud Alarifi, Rafa Almeer, Jawahir Alghamdi, Deeba Ali, A. Alahmari, Mohamed M. Abdel-Daim

finasteride apoptosis pathological changes liver kidney heart estrogen testosterone genotoxicity mutagenicity Propecia

TLDR Finasteride causes harmful organ changes in female mice.

A study conducted on female mice found that long-term treatment with finasteride, a drug used to treat hair loss in men, induced apoptosis and pathological changes in vital organs such as the liver, kidney, and heart. The study suggests caution in any future consideration of finasteride use in females, as even low doses of the drug can have negative effects on females and alter estrogen/testosterone balance, leading to genotoxicity and mutagenicity.

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Research cited in this study

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Guidelines for diagnosing common hair loss include detailed history, clinical examination, and various diagnostic techniques.

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Early diagnosis and treatment, using finasteride, minoxidil, or hair transplantation, improves hair loss outcomes.

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