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GlossaryGenotoxicity

ability of substances to damage cellular genetic information

Genotoxicity refers to the ability of certain substances to damage the genetic information within a cell, causing mutations that may lead to cancer. This term is important in both medical and environmental contexts, as it helps assess the potential risks of chemicals, drugs, and other agents to human health and the environment.

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research Scientific Opinion on the Safety of Coriander Seed Oil as a Novel Food Ingredient

18 citations, October 2013 in “EFSA Journal”

Coriander seed oil is safe for healthy adults at up to 600 mg per day.

research Subchronic Study of Sperm Morphology, Genotoxic and Mutagenic Effect of Lepidium Sativum Seeds Aqueous Extract In Vivo

1 citations, January 2020 in “Recent Research in Genetics and Genomics/Recent Research in Genetics and Genomics ”

High doses of Lepidium sativum seed extract are toxic and should be used with caution.

research Validation of Replacement of the Synthetic Food Dye 'Sunset Yellow'-Induced Hepatotoxicity and Genotoxicity with the Nutraceutical 'Curcumin' in Mice

8 citations, January 2016

Curcumin can safely replace Sunset Yellow as a food colorant.

research Long-Term Treatment with Finasteride Induces Apoptosis and Pathological Changes in Female Mice

3 citations, April 2019 in “Human & Experimental Toxicology”

Finasteride causes harmful organ changes in female mice.

research Xenobiotic-Metabolizing Enzymes in the Skin of Rat, Mouse, Pig, Guinea Pig, Man, and in Human Skin Models

38 citations, June 2018 in “Archives of Toxicology”

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

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