Xenobiotic-Metabolizing Enzymes in the Skin of Rat, Mouse, Pig, Guinea Pig, Man, and in Human Skin Models

    June 2018 in “ Archives of Toxicology ”
    Franz Oesch, Eric Fabian, Robert Landsiedel
    Studysummary This review suggests that skin may largely protect itself from CYP-generated reactive metabolites due to higher conjugating enzyme activities, while highlighting limitations in modeling human skin metabolism experimentally.
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    Research cited in this study 7

    1. Different Patterns of 5α-Reductase Expression, Cellular Distribution, and Testosterone Metabolism in Human Follicular Dermal Papilla Cells Biochemical and Biophysical Research Communications · 2008
    2. Cyclooxygenases in the Skin: Pharmacological and Toxicological Implications Toxicology and applied pharmacology · 2003
    3. Comparison of Glutathione S-Transferase and Cytochrome P-450 IA1 Activities in Cultured Keratinocytes and Reconstructed Epidermal Models Skin Pharmacology and Physiology · 2002
    4. Intracrinology and the Skin Hormone Research in Paediatrics · 2000
    5. A Keratinocyte-Specific Epoxygenase, CYP2B12, Metabolizes Arachidonic Acid with Unusual Selectivity, Producing a Single Major Epoxyeicosatrienoic Acid Journal of biological chemistry/˜The œJournal of biological chemistry · 1998
    6. Sulfate Conjugation of Minoxidil in Rat Skin Biochemical Pharmacology · 1993
    7. Human Hair Follicle Benzo[a]pyrene and Benzo[a]pyrene 7,8-diol Metabolism: Effect of Exposure to a Coal Tar-Containing Shampoo Journal of Investigative Dermatology · 1987