Characterization of Xenobiotic Metabolizing Enzymes of a Reconstructed Human Epidermal Model from Adult Hair Follicles
September 2017
in “
The journal of investigative dermatology/Journal of investigative dermatology
”
reconstructed human epidermal model outer root sheath hair follicles xenobiotic metabolizing enzymes cytochromes P450 CYPs alcohol dehydrogenases aldehyde dehydrogenases carboxyl esterases Phase I XME genes Phase II XMEs GSTs transferases CYP inducers 3-methylcholanthrene beta-naphthoflavone UGTs SULTs 7-ethoxycoumarin testosterone benzo(a)pyrene AhR ligands reconstructed skin model ORS-RHE hair follicle model xenobiotic enzymes CYP enzymes alcohol enzymes aldehyde enzymes esterases Phase I enzymes Phase II enzymes glutathione S-transferases 3-MC BNF UGT enzymes SULT enzymes
Studysummary In this study, the reconstructed skin epidermal model derived from hair follicles showed gene expression and enzyme functionality consistent with native human skin, suggesting its viability for studying skin metabolism and potential toxicity of dermo-cosmetic ingredients.
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