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research Characterization of Xenobiotic Metabolizing Enzymes of a Reconstructed Human Epidermal Model from Adult Hair Follicles

September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.

research Xenobiotic-Metabolizing Enzymes in the Skin of Rat, Mouse, Pig, Guinea Pig, Man, and in Human Skin Models

38 citations , June 2018 in “Archives of Toxicology”

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

research MLL Histone Methylases in Estrogen-Mediated Regulation of HOX Genes Involved in Hair Follicle Development and Leukemia

3 citations , April 2010 in “The FASEB Journal”

Estrogen and MLL enzymes work together to regulate genes important for hair growth and leukemia.

research Enzymes

1 citations , November 2011 in “British journal of pharmacology”

Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.

research Enzyme Inhibitors from Gorgonians and Soft Corals

4 citations , January 2023 in “Marine Drugs”

Marine compounds from gorgonians and soft corals show promise for drug development, especially for chronic disorders.

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community RU-58841 Lung Disease Possibility | Chest pain, "heart issues", etc

in Treatment 21 upvotes 2 years ago

Some users of RU-58841 report cardiovascular symptoms like heart palpitations and chest tightness, which may be linked to its metabolites causing lung disease. The safety of RU-58841 is uncertain due to lack of long-term data and concerns about product purity, especially from gray market sources.

community DHT Itch is real. The connection between Acne and Male Pattern Baldness shows this

in Research/Science 64 upvotes 2 years ago

The conversation discusses the link between seborrheic dermatitis, acne, and male pattern baldness, suggesting that DHT may cause both skin conditions and hair loss. Treatments mentioned include RU58841, finasteride, dutasteride, minoxidil, Nizoral shampoo, and other topical anti-androgens.

community Diffuse thinning is so brutal.

in Styling 72 upvotes 2 years ago

A 25-year-old with AGA experienced hair thinning and dandruff, stabilized with topical finasteride and minoxidil but saw minimal regrowth. They seek advice on styling and consider oral minoxidil and microneedling for denser hair.

community Wrinkly under eyes at 24?! Possible Minoxidil side effect?

in Minoxidil 19 upvotes 5 years ago

A user noticed wrinkling under one eye, possibly due to Minoxidil use. They seek advice on preventing or fixing this issue.

community 6 months on oral minox with no result

in Minoxidil 10 upvotes 3 years ago

A user who had taken oral minoxidil for 6 months without seeing any results and the advice given in response, which included trying microneedling in combination with topical minoxidil, as well as seeking a dermatologist's opinion.

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