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The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

The document concludes that understanding sulfation biology is crucial for creating treatments due to its importance in biological functions and disease.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Minoxidil slows down skin cell growth and may help treat scars and skin conditions.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

Finasteride effectively treats BPH but may increase sexual dysfunction risk.

Understanding phenotypic plasticity is crucial for developing effective cancer therapies.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.

The article suggests managing interferon beta therapy side effects in MS with dose adjustments, medications, and patient education.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

Hair follicle stem cells use specific chromatin changes to control their growth and differentiation.

Sulforaphane from broccoli can help protect skin from sun damage.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

Jumonji genes are important for development and their mutations can cause abnormalities, especially in the heart and brain.

Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

Pig skin is a good substitute for human skin to measure drug absorption, but differences in skin structure and enzymes across species must be considered.

People with PCOS, especially if obese, often have NAFLD, linked to obesity, insulin resistance, and high androgen levels.

Zinc is crucial for nutrition, especially in patients with specific health conditions, and requires careful supplementation and monitoring.

Mutant CDP/Cux protein causes hair defects and reduced male fertility in mice.

Methotrexate reduced the need for steroids in asthma patients without worsening their condition.

ZDHHC13 is important for normal liver function and metabolism, affecting mitochondrial activity.

Human enzymes can detoxify harmful substances but might also increase their cancer risk.

Valproic Acid could potentially be used to treat immune-related conditions due to its ability to modify immune cell functions.

A mother's western diet can make her milk toxic, causing inflammation and hair loss in babies.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.