Genetic Ablation of the CDP/Cux Protein C Terminus Results in Hair Cycle Defects and Reduced Male Fertility

    March 2002 in “ Molecular and cellular biology ”
    Mai X. Luong, Caroline M. van der Meijden, Dongxia Xing, Ruth Hesselton, Edwin S. Monuki, Stephen N. Jones, Jane B. Lian, Janet L. Stein, Gary S. Stein, Ellis J. Neufeld, André J. van Wijnen
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    TLDR Mutant CDP/Cux protein causes hair defects and reduced male fertility in mice.
    The study investigated mice with a mutant CDP/Cux protein lacking the C terminus, which resulted in significantly reduced nuclear localization and loss of DNA binding activity in the nucleus. These homozygous mutant mice exhibited stunted growth, high postnatal death rates (60-70%), sparse abnormal coat hair, and severely reduced fertility. The findings suggested that CDP/Cux is essential for the developmental control of dermal and reproductive functions, as evidenced by the deregulated hair cycle and compromised fertility in the mutant mice.
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