Association Between DNA Methylation in the Core Promoter Region of the CUT-Like Homeobox 1 (CUX1) Gene and Lambskin Pattern in Hu Sheep

September 2023 in “ Genes ”

Xiaoyang Lv, Yue Li, Weihao Chen, Shanhe Wang, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Joram M. Mwacharo, Aynalem Haile, Yutao Li, Wei Sun

DNA methylation core promoter region CUX1 gene hair follicle development

TLDR DNA methylation likely doesn't cause different lambskin patterns in Hu sheep.

The study explored the association between DNA methylation in the core promoter region of the CUX1 gene and lambskin patterns in Hu sheep. Despite identifying core promoter and repressive regions, bisulfite amplicon sequencing showed no significant difference in methylation levels between small wave (SM) and straight wool (ST) patterns, suggesting that differential CUX1 expression is not linked to DNA methylation. However, the research enhances understanding of CUX1's role in hair follicle development, providing valuable insights for the Hu sheep lambskin industry.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

7 / 7 results

research DNA Methylation Mediates LncRNA2919 Regulation of Hair Follicle Regeneration

August 2022 in “International Journal of Molecular Sciences”

DNA methylation controls lncRNA2919, which negatively affects hair growth.

research The Effect of EGR1 on the Proliferation of Dermal Papilla Cells

5 citations, July 2022 in “Genes”

Increasing EGR1 levels makes hair root cells grow faster.

research Analysis of lncRNAs Expression Profiles in Hair Follicles of Hu Sheep Lambskin

17 citations, June 2020 in “Animals”

lncRNAs may regulate hair follicle development in Hu sheep.

Integrative Analysis of Methylome and Transcriptome Reveals the Regulatory Mechanisms of Hair Follicle Morphogenesis in Cashmere Goat

research Integrative Analysis of Methylome and Transcriptome Reveals the Regulatory Mechanisms of Hair Follicle Morphogenesis in Cashmere Goat

24 citations, April 2020 in “Cells”

DNA methylation and long non-coding RNAs are key in controlling hair growth in Cashmere goats.

research Molecular Principles of Hair Follicle Induction and Morphogenesis

479 citations, January 2005 in “BioEssays”

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

research BMP Signaling in the Control of Skin Development and Hair Follicle Growth

165 citations, December 2004 in “Differentiation”

BMP signaling is crucial for skin and hair growth.

research Hair Defects and Pup Loss in Mice with Targeted Deletion of the First Cut Repeat Domain of the Cux/CDP Homeoprotein Gene

48 citations, August 1998 in “Developmental Biology”

Deleting part of a gene in mice causes wavy hair and high pup loss.

Similar Research

5 / 1000+ results

research SP1 and KROX20 Regulate the Proliferation of Dermal Papilla Cells and Target the CUX1 Gene

January 2024 in “Animals”

SP1 promotes and KROX20 inhibits hair cell growth by affecting the CUX1 gene.

research Genome-Wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage

191 citations, September 2011 in “Cell stem cell”

Hair follicle stem cells use specific chromatin changes to control their growth and differentiation.

research Application of Multi-Omics Techniques to Androgenetic Alopecia: Current Status and Perspectives

June 2024 in “Computational and Structural Biotechnology Journal”

Multi-omics techniques help understand the molecular causes of androgenetic alopecia.

research Abstracts

2 citations, January 2019 in “Medizinische Genetik”

The document reports findings on genetic research, including ethical concerns about genome editing, improved diagnosis of mitochondrial mutations, solving inherited eye diseases, confirming gene roles in epilepsy, linking a gene to aneurysms, and identifying genes associated with age-related macular degeneration.

research DNA Methylation Mediates LncRNA2919 Regulation of Hair Follicle Regeneration

August 2022 in “International Journal of Molecular Sciences”

DNA methylation controls lncRNA2919, which negatively affects hair growth.

Association Between DNA Methylation in the Core Promoter Region of the CUT-Like Homeobox 1 (CUX1) Gene and Lambskin Pattern in Hu Sheep

Research cited in this study

research DNA Methylation Mediates LncRNA2919 Regulation of Hair Follicle Regeneration

research The Effect of EGR1 on the Proliferation of Dermal Papilla Cells

research Analysis of lncRNAs Expression Profiles in Hair Follicles of Hu Sheep Lambskin

research Integrative Analysis of Methylome and Transcriptome Reveals the Regulatory Mechanisms of Hair Follicle Morphogenesis in Cashmere Goat

research Molecular Principles of Hair Follicle Induction and Morphogenesis

research BMP Signaling in the Control of Skin Development and Hair Follicle Growth

research Hair Defects and Pup Loss in Mice with Targeted Deletion of the First Cut Repeat Domain of the Cux/CDP Homeoprotein Gene

Related Community Posts Join

community Why is dht bad for scalp hair but good for hair on the rest of body?

community The Real Cause Of Androgenetic Alopecia

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

community Doctor says i shouldn't take fin because its "hormonal"

community C’est terrible - at my wits end

community Long term finasteride users; Did you notice any improvement after 2 years?

Similar Research

research SP1 and KROX20 Regulate the Proliferation of Dermal Papilla Cells and Target the CUX1 Gene

research Genome-Wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage

research Application of Multi-Omics Techniques to Androgenetic Alopecia: Current Status and Perspectives

research Abstracts

research DNA Methylation Mediates LncRNA2919 Regulation of Hair Follicle Regeneration