Unlocking the Genetic Secrets of Dorper Sheep: Insights Into Wool Shedding and Hair Follicle Development

    December 2024 in “ Frontiers in Veterinary Science
    Xiaochun Yuan, Ke Meng, Yayan Wang, Yifan Wang, Cuili Pan, Haoran Sun, Jankui Wang, Xinhai Li
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    TLDR Dorper sheep's wool shedding is linked to specific genes and pathways, which may help understand human hair growth.
    This study explores the genetic mechanisms behind wool shedding and hair follicle development in Dorper sheep, known for their natural wool shedding. Researchers conducted transcriptome analysis on skin tissues from adult Dorper ewes, identifying thousands of differentially expressed transcripts and key signaling pathways such as Rap1, estrogen, PI3K-Akt, and MAPK involved in hair follicle development. Core genes like DBI, FZD3, KRT17, ZDHHC21, TMEM79, and HOXC13 were found to be influential. The study also highlights the role of alternative splicing, particularly the isoforms of ZDHHC21, in hair follicle development. These findings provide insights into the genetic basis of hair follicle development in sheep and have potential implications for understanding human hair growth.
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