Msx2 Supports Epidermal Competency During Wound-Induced Hair Follicle Neogenesis

March 2018 in “ Journal of Investigative Dermatology ”

Michael Hughes, Ting-Xin Jiang, Maksim V. Plikus, Christian F. Guerrero-Juarez, Chien-Hong Lin, Christopher M. Schafer, Robert E. Maxson, Randall B. Widelitz, Cheng-Ming Chuong

Msx2 wound-induced hair follicle neogenesis WIHN hair follicle regeneration wound healing interfollicular epithelium epidermal progenitors ectodermal appendage neogenesis

TLDR The gene Msx2 is crucial for hair follicle regeneration during wound healing.

The study investigates the role of the gene Msx2 in wound-induced hair follicle neogenesis (WIHN), a process of hair follicle regeneration during wound healing. The researchers found that Msx2 is essential for WIHN, with its expression occurring in two phases: early along the wound edge and late in the wound center. The late phase of Msx2 expression is associated with WIHN, and Msx2 positive cells originate from the interfollicular epithelium. The study, involving 16 mice, concluded that Msx2 supports the competency of the epidermis during hair follicle neogenesis, providing insight into mechanisms modulating the competency of adult epidermal progenitors for mammalian ectodermal appendage neogenesis.

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