Increasing GSH-Px Activity and Activating Wnt Pathway Promote Fine Wool Growth in FGF5-Edited Sheep

June 2024 in “ Cells ”

Xueling Xu, Sujuan Wu, Shaohua Qi, Mingming Chen, Zhi Mei Liu, Rui Zhang, Yue Zhao, S.–J. Liu, Wendi Zhou, Jinlong Zhang, Xiaosheng Zhang, Shoulong Deng, Kun Yu, Yan Li, Zhengxing Lian

FGF5 CRISPR/Cas9 Glutathione peroxidase GSH-Px Wnt signaling pathway secondary hair follicle SHF cortisol CRISPR Wnt pathway

TLDR Editing the FGF5 gene in sheep increases fine wool growth.

The study investigated the effects of FGF5 gene editing on wool growth in four Dorper sheep using CRISPR/Cas9. The edited sheep showed significantly increased fine wool density and a higher proportion of fine wool (14.4–20.0 μm). FGF5 editing led to decreased cortisol levels, enhanced antioxidant enzyme activity (including Glutathione peroxidase, GSH-Px), and activated the Wnt signaling pathway, promoting secondary hair follicle (SHF) development. These findings suggest that FGF5 is crucial for SHF growth and could be a molecular marker for fine wool production in sheep breeding.

View this study on mdpi.com →

Discuss this study in the Community →

Similar Research

5 / 383 results

research Screening the Key Genes of Hair Follicle Growth Cycle in Inner Mongolian Cashmere Goat Based on RNA Sequencing

14 citations, May 2020 in “Archiv für Tierzucht”

Researchers identified genes that may affect hair growth in Cashmere goats.

research Transcriptomic Analysis Reveals Critical Genes for the Hair Follicle of Inner Mongolia Cashmere Goat from Catagen to Telogen

25 citations, October 2018 in “PloS one”

Key genes regulate hair follicle phase changes in Inner Mongolia cashmere goats.

research CRISPR/Cas9-Mediated Loss of FGF5 Function Increases Wool Staple Length in Sheep

47 citations, June 2017 in “The FEBS journal”

Disabling the FGF5 gene in sheep leads to longer wool.

CRISPR/Cas9-Mediated Disruption of Fibroblast Growth Factor 5 in Rabbits Results in a Systemic Long Hair Phenotype by Prolonging Anagen

research CRISPR/Cas9-Mediated Disruption of Fibroblast Growth Factor 5 in Rabbits Results in a Systemic Long Hair Phenotype by Prolonging Anagen

13 citations, March 2020 in “Genes”

Disrupting the FGF5 gene in rabbits leads to longer hair by extending the hair growth phase.

research Generation of VEGF Knock-In Cashmere Goat via the CRISPR/Cas9 System

12 citations, January 2021 in “International Journal of Biological Sciences”

Scientists successfully edited a goat's genes to grow more and longer cashmere hair.

Increasing GSH-Px Activity and Activating Wnt Pathway Promote Fine Wool Growth in FGF5-Edited Sheep

Related Community Posts Join

community Mystery compound found to be safe and effective at treating hair loss. Details in comments.

community DIY treatment... Shedding completely stopped after 1.5 yrs