Disruption of FGF5 in Cashmere Goats Using CRISPR/Cas9 Results in More Secondary Hair Follicles and Longer Fibers

    October 2016 in “ PLoS ONE ”
    Xiaolong Wang, Bei Cai, Jiankui Zhou … Yulin Chen
    Studysummary This study found that CRISPR/Cas9-mediated disruption of the FGF5 gene in goats increased hair follicle numbers and fiber length, suggesting more cashmere production could be achieved.
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    Research cited in this study 7

    1. Fibroblast Growth Factor 5-Short (FGF5s) Inhibits the Activity of FGF5 in Primary and Secondary Hair Follicle Dermal Papilla Cells of Cashmere Goats Gene · 2015
    2. FGF5 Is a Crucial Regulator of Hair Length in Humans Proceedings of the National Academy of Sciences of the United States of America · 2014
    3. Growth and Viability of Liaoning Cashmere Goat Hair Follicles During the Annual Hair Follicle Cycle Genetics and Molecular Research · 2014
    4. The Long And The Short Of It: Evidence That FGF5 Is A Major Determinant Of Canine Hair-Itability Animal genetics · 2006
    5. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    6. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    7. Growth of Secondary Hair Follicles of the Cashmere Goat In Vitro and Their Response to Prolactin and Melatonin PubMed · 1994