TLDR CRISPR/Cas9 gene editing in cashmere goats increases hair follicles and fiber length, boosting cashmere yield.
The study demonstrated that using CRISPR/Cas9 technology to disrupt the FGF5 gene in cashmere goats led to an increased number of secondary hair follicles and longer fibers, resulting in a higher cashmere yield. The experiment involved 19 gene-modified goats, with 6 showing single gene disruption, and these goats exhibited significantly longer coat and cashmere fibers compared to controls, with an average increase of 92.75 g of cashmere per animal. The genetic modifications were confirmed at both morphological and genetic levels, and the knockout alleles were likely capable of germline transmission, indicating potential for population expansion. This research highlighted the potential of CRISPR/Cas9 for genetic improvement in livestock.
42 citations
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September 2015 in “Gene” FGF5s can block the effects of FGF5, which may help control hair growth in cashmere goats.
136 citations
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July 2014 in “Proceedings of the National Academy of Sciences of the United States of America” FGF5 gene mutations cause unusually long eyelashes by affecting hair growth regulation.
10 citations
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January 2014 in “Genetics and Molecular Research” Liaoning Cashmere goat hair follicles show synchronized growth patterns with lowest activity in May.
73 citations
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June 2006 in “Animal genetics” The FGF5 gene determines hair length in dogs.
520 citations
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February 2001 in “Journal of Clinical Investigation” VEGF helps hair grow and determines follicle size by increasing blood vessel growth.
1113 citations
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August 1999 in “The New England Journal of Medicine” Hair follicle biology advancements may lead to better hair growth disorder treatments.
56 citations
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August 1994 in “PubMed” Prolactin and melatonin can stimulate hair growth in Cashmere goat hair follicles, but melatonin may reduce follicle viability over time.
March 2024 in “Agriculture” CRISPR/Cas9 gene-editing shows promise for improving sheep and goat breeding but faces challenges with efficiency and accuracy.
5 citations
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November 2022 in “Animal Genetics” Genomic research can help improve the quality and production of natural fibers in animals.
12 citations
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January 2021 in “International Journal of Biological Sciences” Scientists successfully edited a goat's genes to grow more and longer cashmere hair.
Editing the FGF5 gene in sheep increases fine wool growth.
13 citations
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March 2020 in “Genes” Disrupting the FGF5 gene in rabbits leads to longer hair by extending the hair growth phase.
