Progress in Research and Prospects for Application of Precision Gene-Editing Technology Based on CRISPR-Cas9 in the Genetic Improvement of Sheep and Goats

    March 2024 in “ Agriculture
    Zeyu Lu, Lingtian Zhang, Qing Mu … Yanhong Zhao
    Studysummary The researchers reviewed the status, challenges, and future prospects of CRISPR/Cas9-mediated gene-editing technology in livestock breeding, noting its benefits and highlighting concerns about low efficiency in inserting foreign genes and off-target effects.
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    Research cited in this study 4

    1. Crosstalk Between Androgen and Wnt/β-Catenin Leads to Changes in Wool Density in FGF5-Knockout Sheep Cell Death and Disease · 2020
    2. Bioinformatics Analysis of Evolutionary Characteristics and Biochemical Structure of FGF5 Gene in Sheep Gene · 2019
    3. Generation of Tβ4 Knock-In Cashmere Goat Using CRISPR/Cas9 International journal of biological sciences · 2019
    4. Generation of Cashmere Goats Carrying an EDAR Gene Mutant Using CRISPR-Cas9-Mediated Genome Editing International Journal of Biological Sciences · 2018