Gene editing holds promise for skin treatments but needs careful safety and ethical consideration.
March 2024 in “Agriculture” CRISPR/Cas9 gene-editing shows promise for improving sheep and goat breeding but faces challenges with efficiency and accuracy.
CRISPR/Cas9 gene-editing shows promise for livestock breeding but faces challenges like low efficiency and off-target effects.
October 2022 in “Frontiers in Endocrinology” New tools show that in fish, NPY increases feeding and somatostatin decreases it.
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February 2024 in “Pharmaceutics” The study explores the use of echogenic liposomes (ELIP) as carriers for CRISPR/Cas9 complexes to improve gene delivery in cardiovascular therapy. In experiments conducted on mouse neonatal ventricular myocytes and rat hearts, ELIP containing a decoy oligodeoxynucleotide against NF-κB showed limited gene delivery without ultrasound. However, the combination of ELIP and ultrasound significantly enhanced gene penetration into heart cells and tissues. Further tests with ELIP delivering Cas9-sg-IL1RL1 RNA demonstrated successful gene editing, which was further improved by ultrasound. This method holds potential for advancing CRISPR-based gene therapy for heart disease.