The Prospect and Application Research Progress of Precision Gene Editing Technology Based on CRISPR/Cas9 in Livestock Genetics and Breeding

    December 2023
    Zeyu Lu, Lingtian Zhang, Qing Mu, Junyang Liu, Yu Chen, Haoyuan Wang, Yanjun Zhang, Rui Su, Ruijun Wang, Zhiying Wang, Qi Lv, Zhihong Liu, Jiasen Liu, Yunhua Li, Yanhong Zhao
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    TLDR CRISPR/Cas9 gene-editing shows promise for livestock breeding but faces challenges like low efficiency and off-target effects.
    The document reviews the progress and application prospects of CRISPR/Cas9 gene-editing technology in livestock genetics and breeding, particularly focusing on sheep and goats. It highlights the significant advancements made in producing gene-edited livestock, such as pigs, cattle, and sheep, through precise modifications at the genome level. Despite its widespread use, challenges remain, including low insertion efficiency of foreign genes and off-target effects, which limit its application in large livestock like cashmere goats. The review aims to provide a theoretical reference for further research in livestock gene function analysis, genetic improvement, and breeding with local economic characteristics.
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