The Overexpression of Tβ4 in the Hair Follicle Tissue of Alpas Cashmere Goats Increases Cashmere Yield and Promotes Hair Follicle Development

December 2019 in “ Animals ”

Bai Dai, Hao Liang, Dongdong Guo, Zhao-Wei Bi, Jiangzi Yuan, Yifeng Jin, Huan Lei, Xudong Guo, Ming Cang, Dongjun Liu

Thymosin beta-4 Tβ4 hair follicle development cashmere yield secondary hair follicles keratin type II cytoskeletal 4 epidermal KRT4 ERK signaling pathway skin transcriptome proteome hair growth keratin ERK pathway

TLDR Overexpressing Tβ4 in goats' hair follicles increases cashmere production and hair follicle growth.

The study evaluated the role of Thymosin beta-4 (Tβ4) in hair follicle development and cashmere yield by establishing a flock of 15 cashmere goats that overexpressed the Tβ4 gene in their hair follicles. These Tβ4 overexpression (Tβ4-OE) goats had more secondary hair follicles and produced more cashmere compared to wild-type (WT) goats. Analysis of the skin transcriptome and proteome suggested that Tβ4 might promote hair growth by interacting with keratin type II cytoskeletal 4 epidermal (KRT4) and mediating the ERK signaling pathway, leading to increased cashmere yield.

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