The Overexpression of Tβ4 in the Hair Follicle Tissue of Alpas Cashmere Goats Increases Cashmere Yield and Promotes Hair Follicle Development

December 2019 in “ Animals ”

Bai Dai, Hao Liang, Dongdong Guo, Zhao-Wei Bi, Jiangzi Yuan, Yifeng Jin, Huan Lei, Xudong Guo, Ming Cang, Dongjun Liu

Thymosin beta-4 Tβ4 hair follicle development cashmere yield secondary hair follicles keratin type II cytoskeletal 4 epidermal KRT4 ERK signaling pathway skin transcriptome proteome hair growth keratin ERK pathway

TLDR Overexpressing Tβ4 in goats' hair follicles increases cashmere production and hair follicle growth.

The study evaluated the role of Thymosin beta-4 (Tβ4) in hair follicle development and cashmere yield by establishing a flock of 15 cashmere goats that overexpressed the Tβ4 gene in their hair follicles. These Tβ4 overexpression (Tβ4-OE) goats had more secondary hair follicles and produced more cashmere compared to wild-type (WT) goats. Analysis of the skin transcriptome and proteome suggested that Tβ4 might promote hair growth by interacting with keratin type II cytoskeletal 4 epidermal (KRT4) and mediating the ERK signaling pathway, leading to increased cashmere yield.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

8 / 8 results

research Tannic Acid Accelerates Cutaneous Wound Healing in Rats Via Activation of the ERK 1/2 Signaling Pathways

26 citations, April 2019 in “Advances in wound care”

Tannic acid helps wounds heal faster in rats by activating certain cell signals and reducing inflammation.

research Generation of Tβ4 Knock-In Cashmere Goat Using CRISPR/Cas9

17 citations, January 2019 in “International journal of biological sciences”

Researchers used CRISPR/Cas9 to create a goat with a gene that increased cashmere production by 74.5% without affecting quality.

Melatonin Promotes Cashmere Goat (Capra Hircus) Secondary Hair Follicle Growth: A View from Integrated Analysis of Long Non-Coding and Coding RNAs

research Melatonin Promotes Cashmere Goat (Capra Hircus) Secondary Hair Follicle Growth: A View from Integrated Analysis of Long Non-Coding and Coding RNAs

32 citations, May 2018 in “Cell Cycle”

Melatonin helps Cashmere goats grow more hair by affecting certain genes and cell pathways.

research Expression of Vimentin in Hair Follicle Growth Cycle of Inner Mongolian Cashmere Goats

23 citations, January 2018 in “BMC genomics”

Vimentin is involved in regulating the hair growth cycle in Inner Mongolian Cashmere goats.

Skin Transcriptome Reveals the Intrinsic Molecular Mechanisms Underlying Hair Follicle Cycling in Cashmere Goats Under Natural and Shortened Photoperiod Conditions

research Skin Transcriptome Reveals the Intrinsic Molecular Mechanisms Underlying Hair Follicle Cycling in Cashmere Goats Under Natural and Shortened Photoperiod Conditions

24 citations, October 2017 in “Scientific reports”

Changing light exposure can affect hair growth timing in goats, possibly due to a key gene, CSDC2.

research Tβ4-Overexpression Based on the PiggyBac Transposon System in Cashmere Goats Alters Hair Fiber Characteristics

18 citations, November 2016 in “Transgenic research”

Overexpressing Tβ4 in cashmere goats improves hair fiber traits and increases cashmere yield.

research Molecular Characterization, Expression and Methylation Status Analysis of BMP4 Gene in Skin Tissue of Liaoning Cashmere Goat During Hair Follicle Cycle

18 citations, July 2016 in “Genetica”

BMP4 gene is crucial for hair follicle development in Liaoning cashmere goats.

research Thymosin Beta 4 Increases Hair Growth by Activation of Hair Follicle Stem Cells

98 citations, December 2003 in “The FASEB Journal”

Thymosin β4 promotes hair growth by activating stem cells in hair follicles.

Related Research

4 / 4 results

research Shedding Light on Cashmere Goat Hair Follicle Biology: From Morphology Analyses to Transcriptomic Landscape

8 citations, July 2020 in “BMC genomics”

The research found genes that change during cashmere goat hair growth and could help determine the best time to harvest cashmere.

research Exploring Differentially Expressed Genes by RNA-Seq in Cashmere Goat Skin During Hair Follicle Development and Cycling

61 citations, April 2013 in “PloS one”

The study found key genes and pathways involved in cashmere goat hair growth stages.

research Hoxc13/β-Catenin Correlation with Hair Follicle Activity in Cashmere Goat

22 citations, July 2012 in “Journal of integrative agriculture/Journal of Integrative Agriculture”

Hoxc13 is linked to seasonal hair growth in Cashmere goats and is affected by melatonin.

research Hair Keratin Pattern in Human Hair Follicles Grown In Vitro

29 citations, April 2003 in “Experimental dermatology”

Human hair follicles grown in vitro maintain normal keratin patterns and structure.