The Overexpression of Tβ4 in the Hair Follicle Tissue of Alpas Cashmere Goats Increases Cashmere Yield and Promotes Hair Follicle Development

    December 2019 in “ Animals ”
    Bai Dai, Hao Liang, Dongdong Guo … Dongjun Liu
    Studysummary In this study, cashmere goats engineered to overexpress the Tβ4 gene in hair follicles produced more cashmere, indicating that Tβ4 promotes secondary hair follicle development and enhances yield.
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    Research cited in this study 15

    1. Tannic Acid Accelerates Cutaneous Wound Healing in Rats Via Activation of the ERK 1/2 Signaling Pathways Advances in wound care · 2019
    2. Generation of Tβ4 Knock-In Cashmere Goat Using CRISPR/Cas9 International journal of biological sciences · 2019
    3. Melatonin Promotes Cashmere Goat (Capra Hircus) Secondary Hair Follicle Growth: A View from Integrated Analysis of Long Non-Coding and Coding RNAs Cell Cycle · 2018
    4. Expression of Vimentin in Hair Follicle Growth Cycle of Inner Mongolian Cashmere Goats BMC genomics · 2018
    5. Generation of Cashmere Goats Carrying an EDAR Gene Mutant Using CRISPR-Cas9-Mediated Genome Editing International Journal of Biological Sciences · 2018
    6. Skin Transcriptome Reveals the Intrinsic Molecular Mechanisms Underlying Hair Follicle Cycling in Cashmere Goats Under Natural and Shortened Photoperiod Conditions Scientific reports · 2017
    7. Tβ4-Overexpression Based on the PiggyBac Transposon System in Cashmere Goats Alters Hair Fiber Characteristics Transgenic research · 2016
    8. Disruption of FGF5 in Cashmere Goats Using CRISPR/Cas9 Results in More Secondary Hair Follicles and Longer Fibers PLoS ONE · 2016
    9. Molecular Characterization, Expression and Methylation Status Analysis of BMP4 Gene in Skin Tissue of Liaoning Cashmere Goat During Hair Follicle Cycle Genetica · 2016
    10. Role of Thymosin Beta 4 in Hair Growth Molecular Genetics and Genomics · 2016
    11. Thymosin Beta-4 Induces Mouse Hair Growth PLoS ONE · 2015
    12. Transcriptome Sequencing Reveals Differences Between Primary and Secondary Hair Follicle-Derived Dermal Papilla Cells of the Cashmere Goat PLoS ONE · 2013
    13. Thymosin Beta 4 Induces Hair Growth Via Stem Cell Migration And Differentiation Annals of the New York Academy of Sciences · 2007
    14. Thymosin Beta 4 Promotes Angiogenesis, Wound Healing, and Hair Follicle Development Mechanisms of Ageing and Development · 2003
    15. Thymosin Beta 4 Increases Hair Growth by Activation of Hair Follicle Stem Cells The FASEB Journal · 2003

    Related research 6

    1. Shedding Light on Cashmere Goat Hair Follicle Biology: From Morphology Analyses to Transcriptomic Landscape BMC genomics · 2020
    2. Exploring Differentially Expressed Genes by RNA-Seq in Cashmere Goat Skin During Hair Follicle Development and Cycling PloS one · 2013
    3. Hoxc13/β-Catenin Correlation with Hair Follicle Activity in Cashmere Goat Journal of integrative agriculture/Journal of Integrative Agriculture · 2012
    4. Keratins of the Human Hair Follicle International review of cytology · 2005
    5. Hair Follicle Differentiation And Regulation The International Journal of Developmental Biology · 2004
    6. Hair Keratin Pattern in Human Hair Follicles Grown In Vitro Experimental dermatology · 2003