Molecular Characterization, Expression and Methylation Status Analysis of BMP4 Gene in Skin Tissue of Liaoning Cashmere Goat During Hair Follicle Cycle

July 2016 in “ Genetica ”

Wen L. Bai, Yun L. Dang, Jiao J. Wang, Rong Yin, Ze Y. Wang, Yanbing Zhu, Yu Y. Cong, Hui Xue, Dong Liang, Dan Guo, Shi Q. Wang, Shu Yang

BMP4 gene hair follicle development anagen telogen methylation 5′ flanking regulatory region mRNA expression epigenetic regulation BMP4 hair growth cycle gene expression

TLDR BMP4 gene is crucial for hair follicle development in Liaoning cashmere goats.

The study investigated the BMP4 gene in Liaoning cashmere goats, focusing on its role in hair follicle development and cycle. Researchers found that the BMP4 cDNA was 1264-bp long, encoding a 409 amino acid precursor peptide. BMP4 transcription increased from anagen to telogen stages, and higher methylation levels in the 5′ flanking regulatory region were linked to lower BMP4 mRNA expression. These results highlighted BMP4's significant role in hair follicle development and its epigenetic regulation in these goats.

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