Molecular Characterization, Expression and Methylation Status Analysis of BMP4 Gene in Skin Tissue of Liaoning Cashmere Goat During Hair Follicle Cycle

July 2016 in “ Genetica ”

Wen L. Bai, Yun L. Dang, Jiao J. Wang, Rong Yin, Ze Y. Wang, Yanbing Zhu, Yu Y. Cong, Hui Xue, Dong Liang, Dan Guo, Shi Q. Wang, Shu Yang

BMP4 gene hair follicle development anagen telogen methylation 5′ flanking regulatory region mRNA expression epigenetic regulation BMP4 hair growth cycle gene expression

Studysummary This study found that in Liaoning cashmere goats, the BMP4 gene shows increased transcription from the anagen stage to telogen, and higher gene methylation correlates with reduced expression in skin tissue.

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The study investigated the BMP4 gene in Liaoning cashmere goats, focusing on its role in hair follicle development and cycle. Researchers found that the BMP4 cDNA was 1264-bp long, encoding a 409 amino acid precursor peptide. BMP4 transcription increased from anagen to telogen stages, and higher methylation levels in the 5′ flanking regulatory region were linked to lower BMP4 mRNA expression. These results highlighted BMP4's significant role in hair follicle development and its epigenetic regulation in these goats.

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research Construction of a cDNA Library and Identification of Genes from Liaoning Cashmere Goat

6 citations , March 2014 in “Livestock science”

This study successfully constructed a skin cDNA library from the Liaoning cashmere goat during follicle anagen and identified two genes with significant expression in heart, skin, and hair follicles.

research Transcriptome Sequencing Reveals Differences Between Primary and Secondary Hair Follicle-Derived Dermal Papilla Cells of the Cashmere Goat

81 citations , September 2013 in “PLoS ONE”

This study identified gene expression differences between dermal papilla cells from primary and secondary hair follicles in Cashmere goats, highlighting their roles in hair follicle morphogenesis.

Molecular Characterization, Expression and Methylation Status Analysis of BMP4 Gene in Skin Tissue of Liaoning Cashmere Goat During Hair Follicle Cycle

Research cited in this study

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