Regulation of Secondary Hair Follicle Cycle in Cashmere Goats by miR-877-3p Targeting IGFBP5 Gene

January 2023 in “ Journal of Animal Science ”

Cuiling Wu, Liang Yuan, Wenzhi Cao, Xiaofang Ye, Xiaolin Ma, Chongkai Qin, Bin Li, Fei‐Hai Yu, Xuefeng Fu

TLDR miR-877-3p can improve cashmere quality by regulating hair growth in goats.

This study investigated the regulation of miRNAs in the secondary hair follicles of Jiangnan cashmere goats to enhance cashmere quality. Using high-throughput sequencing, 193 differentially expressed miRNAs were identified during various hair follicle cycle stages. The study focused on chi-miR-877-3p, which was down-regulated during the telogen phase, while its target, the IGFBP5 gene, was up-regulated. Validation experiments showed that overexpression of chi-miR-877-3p in dermal papilla cells suppressed IGFBP5 expression and promoted cell proliferation. These findings provided new insights into the hair follicle cycle regulation in cashmere goats.

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