Micro-RNA-31 Controls Hair Cycle-Associated Changes in Gene Expression Programs of the Skin and Hair Follicle

June 2010 in “ The FASEB journal ”

Andrei N. Mardaryev, Mohammed I. Ahmed, Nikola Vlahov, Michael Y. Fessing, Jason H. Gill, Andrey A. Sharov, Natalia V. Botchkareva

micro-RNA-31 miR-31 hair cycle anagen phase FGF signaling pathway BMP signaling pathway Wnt signaling pathway Dlx3 transcription factor hair shaft formation outer root sheath morphology hair follicle growth hair fiber formation hair growth disorders

Studysummary In this study, miR-31 was found to play a significant role in hair cycle regulation in mice by controlling key gene expressions involved in hair growth and differentiation.

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The study demonstrated that micro-RNA-31 (miR-31) played a crucial role in regulating gene expression during the hair cycle in mice, particularly during the anagen phase. Inhibition of miR-31 led to significant changes in the expression of 419 genes, including those involved in the FGF, BMP, and Wnt signaling pathways, and the Dlx3 transcription factor. This resulted in accelerated anagen progression, altered hair shaft formation, and changes in outer root sheath morphology. The findings suggested that miR-31 is vital for maintaining the balance of gene expression necessary for proper hair follicle growth and hair fiber formation, highlighting its potential as a target for treating hair growth disorders.

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Research cited in this study

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