Involvement of the Edar Signaling in the Control of Hair Follicle Involution (Catagen)

December 2006 in “ The American journal of pathology ”

Michael Y. Fessing, Tatyana Sharova, Andrey A. Sharov, Ruzanna Atoyan, Vladimir A. Botchkarev

Studysummary This study found that Edar signaling plays a role in regulating the hair cycle and apoptosis in hair follicle keratinocytes during the catagen phase in mice. Our plain-language summary of this paper — not a Tressless recommendation.

The study demonstrated that Edar signaling played a crucial role in the regulation of hair follicle (HF) cycling, particularly during the transition from anagen to catagen, by inhibiting apoptosis in the outer root sheath keratinocytes. Disruption of Edar signaling, either through genetic ablation or pharmacological inhibition, accelerated catagen and increased apoptosis markers like TUNEL-positive cells and activated caspase 3. The findings suggested that Edar signaling might control the expression of XIAP, an anti-apoptotic protein, indicating potential therapeutic applications of Edar agonists/antagonists for treating hair growth abnormalities.

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