Involvement of the Edar Signaling in the Control of Hair Follicle Involution (Catagen)
December 2006
in “
The American journal of pathology
”
Edar signaling hair follicle cycling anagen catagen apoptosis outer root sheath keratinocytes genetic ablation pharmacological inhibition TUNEL-positive cells activated caspase 3 XIAP anti-apoptotic protein Edar agonists Edar antagonists hair growth cycle hair growth phase cell death outer root sheath cells genetic removal drug inhibition cell death markers caspase 3 anti-cell death protein Edar activators Edar blockers
TLDR Edar signaling is crucial for controlling hair growth and regression.
The study demonstrated that Edar signaling played a crucial role in the regulation of hair follicle (HF) cycling, particularly during the transition from anagen to catagen, by inhibiting apoptosis in the outer root sheath keratinocytes. Disruption of Edar signaling, either through genetic ablation or pharmacological inhibition, accelerated catagen and increased apoptosis markers like TUNEL-positive cells and activated caspase 3. The findings suggested that Edar signaling might control the expression of XIAP, an anti-apoptotic protein, indicating potential therapeutic applications of Edar agonists/antagonists for treating hair growth abnormalities.
