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Glossary TUNEL-positive cells

cells undergoing programmed cell death with fragmented DNA

TUNEL-positive cells are cells that have been identified as undergoing apoptosis, or programmed cell death. The TUNEL (Terminal deoxynucleotidyl transferase dUTP Nick End Labeling) assay is a laboratory technique used to detect DNA fragmentation, a hallmark of apoptosis, by labeling the ends of broken DNA strands. This helps researchers and medical professionals understand cell death processes in various conditions, including diseases and tissue development.

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Research

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research The premature catagen induced by estrogen was accompanied with advance apoptosis of precortex cells.

December 2015 in “OPAL (Open@LaTrobe) (La Trobe University)”

This study found that estrogen treatment induced premature catagen and apoptosis in hair follicles of wild-type mice, while having no effect on mice lacking estrogen receptor α.

research Involvement of the Edar Signaling in the Control of Hair Follicle Involution (Catagen)

43 citations , December 2006 in “The American journal of pathology”

This study found that Edar signaling plays a role in regulating the hair cycle and apoptosis in hair follicle keratinocytes during the catagen phase in mice.

research Foot shock stress prolongs the telogen stage of the spontaneous hair cycle in a non‐depilated mouse model

31 citations , April 2007 in “Experimental Dermatology”

This study found that foot shock stress prolonged the telogen stage and delayed anagen induction in the hair cycle of non-depilated mice, potentially through stress-induced actions of substance P.

research Beneficial Effects of Astragaloside IV for Hair Loss via Inhibition of Fas/Fas L-Mediated Apoptotic Signaling

29 citations , March 2014 in “PloS one”

In this study, Astragaloside IV was found to inhibit apoptosis-related pathways in hair follicles of mice, suggesting it may serve as an alternative therapy for hair loss.

research Assessment of markers expressed in human hair follicles according to different skin regions

6 citations , July 2018 in “Advances in Clinical and Experimental Medicine”

This study found that scalp hair follicles had higher expression of cytokeratin 15 and distinct hair layers compared to other body regions, highlighting differences in hair follicle characteristics.

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community PP405 Won’t Work: Follicle Is Miniaturized, Fibrosed, And Missing Key Support Cells

7 months ago

PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stem cells, but minoxidil and finasteride are still the main treatments.

community Guys… Pelage might just be the one. They might actually find the cure. I work in tech - let me explain.

196 upvotes 1 year ago

Pelage, backed by Google Ventures, is seen as a promising company potentially finding a cure for hair loss using stem cell activation. There is skepticism and optimism among users, with some awaiting results from ongoing trials.

community How far are we from a treatment better than finasteride?

in Treatment 129 upvotes 1 year ago

Dutasteride is more effective than finasteride for hair loss as it blocks more of the enzyme causing hair loss. New treatments like stem cell therapies and alternatives to minoxidil are being explored, but major advancements are still years away.

community PP405 Phase 2a press release with early results

700 upvotes 1 year ago

PP405 shows promise in hair regrowth, with 31% of participants experiencing over 20% increase in hair density after 8 weeks. Phase 3 trials are expected in 2026, with potential market availability by 2029-2031.

community Thoughts on the future of pp405?

43 upvotes 10 months ago

PP405 is considered a promising hair loss treatment, potentially replacing minoxidil but not finasteride. Users are hopeful for future treatments like GT20029 and VDPHL01, while remaining cautious about effectiveness and side effects.

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