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Glossary Cochlear Hair Cells

specialized inner ear cells that convert sound into signals

Cochlear hair cells are specialized sensory cells located in the cochlea of the inner ear. They play a crucial role in hearing by converting sound vibrations into electrical signals that the brain can interpret. There are two types: inner hair cells, which primarily send auditory information to the brain, and outer hair cells, which amplify and fine-tune sound vibrations. Damage to these cells can lead to hearing loss.

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research Rapamycin but not acarbose decreases age-related loss of outer hair cells in the mouse Cochlea

15 citations , September 2018 in “Hearing research”

This study suggests that rapamycin, but not acarbose, can delay age-related loss of cochlear outer hair cells in UM-HET3 mice at doses that increase life span.

research Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice

8 citations , June 2021 in “International Journal of Molecular Sciences”

In this study, UCMSC exosomes showed protective effects against cisplatin-induced hearing loss in mice by improving hearing and promoting cochlear tissue repair.

research Melatonin Alleviates the Oxygen–Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1,2/Nrf2 (NFE2L2)/ROS/NLRP3 Pathway

5 citations , November 2022 in “Molecular Neurobiology”

Melatonin may protect inner ear cells from damage by reducing cell death and oxidative stress, potentially treating sudden hearing loss.

research Melatonin protects cochlear hair cells from nicotine‐induced injury through inhibiting apoptosis, inflammation, oxidative stress and endoplasmic reticulum stress

5 citations , July 2021 in “Basic & Clinical Pharmacology & Toxicology”

This study found that nicotine caused damage to cochlear hair cells in vitro, and melatonin might protect against this damage, indicating its potential as a treatment for smoking-induced hearing loss.

research Inositol hexaphosphate alleviates ototoxicity and age‐related hearing loss by preserving cochlear hair cells in mice

November 2025 in “British Journal of Pharmacology”

This study found that inositol hexaphosphate significantly reduced hearing threshold shifts and outer hair cell loss in various sensorineural hearing loss mouse models, suggesting potential for otoprotective use.

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