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research Caffeine Induces Autophagy and Apoptosis in Auditory Hair Cells via the SGK1/HIF-1α Pathway

5 citations , November 2021 in “Frontiers in Cell and Developmental Biology”

Caffeine can damage hearing cells and affect hearing recovery after ear trauma.

research MSC-derived exosomes protect auditory hair cells from neomycin-induced damage via autophagy regulation

January 2024 in “Biological Research”

This study found that mesenchymal stem cell-derived exosomes reduced hearing and hair cell loss caused by neomycin in experimental models by modulating autophagy, which promoted cell survival and lowered oxidative stress and apoptosis, indicating potential for deafness treatment.

research Auditory Threshold Variability in the SAMP8 Mouse Model of Age-Related Hearing Loss: Functional Loss and Phenotypic Change Precede Outer Hair Cell Loss

13 citations , August 2021 in “Frontiers in Aging Neuroscience”

This study found that in SAMP8 mice, phenotypic changes in outer hair cells or the stria vascularis, possibly due to oxidative deficiencies, may predict variability in age-related hearing loss before outer hair cell loss occurs.