Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice

June 2021 in “ International Journal of Molecular Sciences ”

Stella Chin-Shaw Tsai, Kuender D. Yang, Kuang-Hsi Chang, Frank R. Lin, Ruey Hwang Chou, Min-Chih Li, Ching-Chang Cheng, Chien-Yu Kao, Chie-Pein Chen, Hung-Ching Lin, Yi-Chao Hsu

umbilical cord mesenchymal stromal cells exosomes cochlear hair cells cisplatin ototoxicity SNHL tissue remodeling repair UCMSC hearing loss cochlea

TLDR Exosomes from umbilical cord cells fix hearing loss and damaged ear hair cells in mice.

Umbilical cord mesenchymal stromal cell-derived exosomes were found to improve hearing loss and rescue the loss of cochlear hair cells in mice receiving chronic cisplatin injection. The treatment also led to beneficial changes in the expression levels of many genes in the cochlear tissues of cisplatin-injected mice, suggesting potential applications in treating ototoxicity-induced hearing loss by promoting tissue remodeling and repair. UCMSC exosomes may have therapeutic potential for treating SNHL and may be a useful therapeutic strategy to repair damaged cochlea.

View this study on mdpi.com →

Discuss this study in the Community →

Similar Research

5 / 857 results

research MSC-Derived Exosomes Protect Auditory Hair Cells From Neomycin-Induced Damage Via Autophagy Regulation

January 2024 in “Biological Research”

Tiny particles from stem cells can help protect ear cells from antibiotic damage by helping cells remove damaged parts.

research Status of Research on the Development and Regeneration of Hair Follicles

November 2023 in “International Journal of Medical Sciences”

New regenerative medicine-based therapies for hair loss look promising but need more clinical validation.

DNA Dioxygenases Tet1/2/3 Control Hair Matrix Keratinocyte Differentiation and Hair Shaft Shape via Regulation of Hair Keratin Gene Expression

research DNA Dioxygenases Tet1/2/3 Control Hair Matrix Keratinocyte Differentiation and Hair Shaft Shape via Regulation of Hair Keratin Gene Expression

July 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

The enzymes Tet1, Tet2, and Tet3 are important for the development of hair follicles and determining hair shape by controlling hair keratin genes.

research Multimodal Imaging of Hair Follicle Bulge-Derived Stem Cells in a Mouse Model of Traumatic Brain Injury

4 citations, February 2020 in “Cell & tissue research/Cell and tissue research”

Hair follicle stem cells might help treat traumatic brain injury.

research Tissue Engineering and Regenerative Medicine: Achievements, Future, and Sustainability in Asia

119 citations, March 2020 in “Frontiers in Bioengineering and Biotechnology”

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice

Related Community Posts Join

community New and Interesting HairLoss Studies/Papers/Reviews

community Calecim (PTT-6) Advanced Hair System with Topical Exosomes and Growth Factors for Hair Growth

community Can we have a thread that summarizes all treatments options in addition to the big 3 which we have some evidence for, their mechanism of action and whether they can be combined with the big 3(other than dermarolling)?