Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice

June 2021 in “ International Journal of Molecular Sciences ”

Stella Chin-Shaw Tsai, Kuender D. Yang, Kuang-Hsi Chang, Frank R. Lin, Ruey Hwang Chou, Min-Chih Li, Ching-Chang Cheng, Chien-Yu Kao, Chie-Pein Chen, Hung-Ching Lin, Yi-Chao Hsu

umbilical cord mesenchymal stromal cells exosomes cochlear hair cells cisplatin ototoxicity SNHL tissue remodeling repair UCMSC hearing loss cochlea

TLDR Exosomes from umbilical cord cells fix hearing loss and damaged ear hair cells in mice.

Umbilical cord mesenchymal stromal cell-derived exosomes were found to improve hearing loss and rescue the loss of cochlear hair cells in mice receiving chronic cisplatin injection. The treatment also led to beneficial changes in the expression levels of many genes in the cochlear tissues of cisplatin-injected mice, suggesting potential applications in treating ototoxicity-induced hearing loss by promoting tissue remodeling and repair. UCMSC exosomes may have therapeutic potential for treating SNHL and may be a useful therapeutic strategy to repair damaged cochlea.

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