MSC-Derived Exosomes Protect Auditory Hair Cells From Neomycin-Induced Damage Via Autophagy Regulation

    January 2024 in “ Biological Research ”
    Huan Liu, Huijuan Kuang, Yiru Wang … Shiyu Liu
    Studysummary This study found that mesenchymal stem cell-derived exosomes reduced hearing and hair cell loss caused by neomycin in experimental models by modulating autophagy, which promoted cell survival and lowered oxidative stress and apoptosis, indicating potential for deafness treatment.
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    Research cited in this study 2

    1. Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice International Journal of Molecular Sciences · 2021
    2. Exosomes Mediate Sensory Hair Cell Protection in the Inner Ear Journal of Clinical Investigation · 2020