Exosomes Mediate Sensory Hair Cell Protection in the Inner Ear

May 2020 in “ Journal of Clinical Investigation ”

Andrew M. Breglio, Lindsey A. May, Melanie Barzik, Nora C Welsh, Shimon P. Francis, Tucker Costain, Lizhen Wang, D. Eric Anderson, Ronald S. Petralia, Ya-Xian Wang, Thomas B. Friedman, Matthew J.A. Wood, Lisa L. Cunningham

exosomes sensory hair cells inner ear heat shock nanoparticle tracking analysis exosome purification transmission electron microscopy exogenous exosomes exosome biogenesis

TLDR Exosomes are crucial for protecting sensory hair cells in the inner ear.

In 2020, researchers conducted a study using various strains of mice to explore the role of exosomes in protecting sensory hair cells in the inner ear. They used a range of techniques including heat shock, nanoparticle tracking analysis, exosome purification, and transmission electron microscopy. They also applied exogenous exosomes and inhibited exosome biogenesis pharmacologically. The study involved a significant number of utricles (9 to 44 per experiment), and the experiments were repeated multiple times for accuracy. The study concluded that exosomes play a crucial role in protecting sensory hair cells in the inner ear.

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research Exosomes Mediate Sensory Hair Cell Protection in the Inner Ear

49 citations, May 2020 in “Journal of Clinical Investigation”

Exosomes are crucial for protecting sensory hair cells in the inner ear.