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GlossaryAutophagy

natural process where cells recycle their own components

Autophagy is a natural process in which cells break down and recycle their own components. This helps to remove damaged or unnecessary parts, allowing the cell to maintain its health and function properly. For professionals, it's a crucial mechanism for cellular homeostasis and can be involved in responses to stress, nutrient deprivation, and even in the development of diseases like cancer and neurodegeneration.

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research Stimulation of Hair Growth by Small Molecules That Activate Autophagy

88 citations, June 2019 in “Cell reports”

Certain small molecules can promote hair growth by activating a cellular cleanup process called autophagy.

research Air Pollution, Autophagy, and Skin Aging: Impact of Particulate Matter on Human Dermal Fibroblasts

68 citations, September 2018 in “International Journal of Molecular Sciences”

Air pollution (PM10) increases skin inflammation and aging by reducing collagen and may trigger a repair response in skin cells.

research FLCN, A Novel Autophagy Component, Interacts With GABARAP And Is Regulated By ULK1 Phosphorylation

60 citations, July 2014 in “Autophagy”

The protein FLCN is involved in cellular cleanup and is regulated by ULK1.

research Autophagy Is Essential for Maintaining the Growth of a Human Mini-Organ: Evidence from Scalp Hair Follicle Organ Culture

42 citations, March 2018 in “PLOS Biology”

Autophagy is important for human hair growth and health.

Long-Term Oral Administration of 5α-Reductase Inhibitor Attenuates Erectile Function by Inhibiting Autophagy and Promoting Apoptosis of Smooth Muscle Cells in Corpus Cavernosum of Aged Rats

research Long-Term Oral Administration of 5α-Reductase Inhibitor Attenuates Erectile Function by Inhibiting Autophagy and Promoting Apoptosis of Smooth Muscle Cells in Corpus Cavernosum of Aged Rats

34 citations, September 2013 in “Urology”

Long-term use of a certain medication can worsen erectile function in aged rats by damaging penile muscle cells.

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community Bruteforcing alopecia or the new advent of science progress

in Research/Science 21 upvotes 4 weeks ago

Combining therapies like scyllo-inositol, alpha-ketoglutarate, and autophagy-inducing supplements may enhance hair growth and prevent hair loss. Reporting individual results can accelerate progress in hair loss treatments.

community Research suggests that drugs rapamycin and metformin have hair regeneration properties

2 upvotes 6 years ago

Rapamycin and metformin may have hair regeneration properties. Specific treatments discussed include Minoxidil, finasteride, and RU58841.

community Ruxolitinib - Start of a case study

in Research/Science 10 upvotes 8 months ago

The conversation is about a user trying a new hair loss treatment, Ruxolitinib, alongside their existing regimen of finasteride, minoxidil, ketoconazole shampoo, and microneedling. They plan to apply Ruxolitinib to their temples daily for 1-2 months.

community Topical rapamycin, metformin, a-kg grow hair

in Research/Science 14 upvotes 4 years ago

The conversation discusses the potential of topical rapamycin, metformin, and alpha-ketoglutarate (a-KG) for hair growth, with skepticism expressed about their effectiveness based on personal experience and existing use. It also mentions AICAR, known as cardarine or GW, which is not suitable for long-term use due to cancer risks in animal studies and its similarity to metformin.

community Minoxidil actually reduces wrinkles

in Research/Science 209 upvotes 1 month ago

Minoxidil may improve or worsen skin quality, with topical forms causing dryness and wrinkles, possibly due to alcohol content, while oral forms have fewer side effects. Some users consider using tretinoin to mitigate negative effects.

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