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GlossaryAutophagy

natural process where cells recycle their own components

Autophagy is a natural process in which cells break down and recycle their own components. This helps to remove damaged or unnecessary parts, allowing the cell to maintain its health and function properly. For professionals, it's a crucial mechanism for cellular homeostasis and can be involved in responses to stress, nutrient deprivation, and even in the development of diseases like cancer and neurodegeneration.

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research Modulating Aging and Aging-Related Symptoms Using Endogenous Small Molecules

January 2019

A molecule called α-ketobutyrate was found to extend lifespan and improve aging-related symptoms in worms and mice by activating certain cellular pathways and may help develop anti-aging treatments for humans.

research Molecular Mechanism of Polygonum Multiflorum in the Treatment of Androgenic Alopecia: Based on Bioinformatics and Molecular Docking Method

April 2022 in “DOAJ (DOAJ: Directory of Open Access Journals)”

Polygonum multiflorum may treat hair loss by reducing inflammation and stress, and boosting melanin.

Autophagy-Related Protein 12 Associates With Anti-Apoptotic B Cell Lymphoma-2 to Promote Apoptosis in Gentamicin-Induced Inner Ear Hair Cell Loss

research Autophagy-Related Protein 12 Associates With Anti-Apoptotic B Cell Lymphoma-2 to Promote Apoptosis in Gentamicin-Induced Inner Ear Hair Cell Loss

2 citations , April 2017 in “Molecular Medicine Reports”

Blocking autophagy increases survival of inner ear hair cells exposed to gentamicin.

research A Connection Between the Mitochondrial Permeability Transition Pore, Autophagy, and Cerebral Amyloidogenesis

14 citations , May 2008 in “Journal of proteome research”

Dutasteride may help reduce brain plaque linked to Alzheimer's by affecting cell energy structures and waste removal.

research BMP2-Mediated PTEN Enhancement Promotes Differentiation of Hair Follicle Stem Cells by Inducing Autophagy

24 citations , September 2019 in “Experimental cell research”

BMP2 helps hair follicle stem cells become specialized by increasing PTEN, which causes autophagy.

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community Ruxolitinib - Start of a case study

in Research/Science 10 upvotes 1 year ago

The conversation is about a user trying a new hair loss treatment, Ruxolitinib, alongside their existing regimen of finasteride, minoxidil, ketoconazole shampoo, and microneedling. They plan to apply Ruxolitinib to their temples daily for 1-2 months.

community Research suggests that drugs rapamycin and metformin have hair regeneration properties

2 upvotes 7 years ago

Rapamycin and metformin may have hair regeneration properties. Specific treatments discussed include Minoxidil, finasteride, and RU58841.

community Topical rapamycin, metformin, a-kg grow hair

in Research/Science 13 upvotes 5 years ago

The conversation discusses the potential of topical rapamycin, metformin, and alpha-ketoglutarate (a-KG) for hair growth, with skepticism expressed about their effectiveness based on personal experience and existing use. It also mentions AICAR, known as cardarine or GW, which is not suitable for long-term use due to cancer risks in animal studies and its similarity to metformin.

community Age-linked hair loss caused by disappearing collagen, researchers say

58 upvotes 6 years ago

Age-linked hair loss is linked to disappearing collagen. Treatments discussed include minoxidil, finasteride, RU58841, tretinoin, microneedling, and collagen supplements.

community [Nov 2019] The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression

21 upvotes 6 years ago

A peptide from Japanese water chestnut fruit may help with hair loss by suppressing DHT's effect on hair follicle cell death, potentially serving as a finasteride alternative. The treatment's effectiveness and safety in humans remain uncertain.

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