BMP2-Mediated PTEN Enhancement Promotes Differentiation of Hair Follicle Stem Cells by Inducing Autophagy

    September 2019 in “ Experimental cell research ”
    Bingjie Cai, Yunpeng Zheng, Jiadi Yan … Guangwen Yin
    Studysummary This study found that BMP2 increased PTEN expression and induced autophagy, promoting hair follicle stem cell differentiation in both in vitro models and a mouse wound model.
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    Research cited in this study 10

    1. Hair Follicle Stem Cell Fate Is Dependent on Chromatin Remodeling Capacity Following Low-Dose Radiation Stem cells · 2017
    2. Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation Nature cell biology · 2017
    3. PTEN Mediates Activation of Core Clock Protein BMAL1 and Accumulation of Epidermal Stem Cells Stem cell reports · 2017
    4. Msi2 Maintains Quiescent State of Hair Follicle Stem Cells by Directly Repressing the Hedgehog Signaling Pathway Journal of Investigative Dermatology · 2017
    5. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    6. Hair Follicle Stem Cell Cultures Reveal Self-Organizing Plasticity of Stem Cells and Their Progeny The EMBO Journal · 2016
    7. Expansion of Hair Follicle Stem Cells Sticking to Isolated Sebaceous Glands to Generate In Vivo Epidermal Structures Cell Transplantation · 2016
    8. Neural Stem Cells Restore Hair Growth Through Activation of the Hair Follicle Niche Cell Transplantation · 2016
    9. Hair Follicle Stem Cells: In Vitro and In Vivo Neural Differentiation World journal of stem cells · 2015
    10. Smad1 and Smad5 but Not Smad8 Establish Stem Cell Quiescence Critical for Transforming Premature Hair Follicles During Morphogenesis to the Postnatal State Stem Cells · 2013