BMP2-Mediated PTEN Enhancement Promotes Differentiation of Hair Follicle Stem Cells by Inducing Autophagy

September 2019 in “ Experimental cell research ”

Bingjie Cai, Yunpeng Zheng, Jiadi Yan, Junmin Wang, Xiaojun Liu, Guangwen Yin

BMP2 PTEN hair follicle stem cells autophagy epidermal markers adipogenic markers keratinocyte-specific markers wound contraction epidermal regeneration bone morphogenetic protein 2 phosphatase and tensin homolog HFSCs skin repair

TLDR BMP2 helps hair follicle stem cells become specialized by increasing PTEN, which causes autophagy.

The study demonstrated that BMP2 promoted the differentiation of hair follicle stem cells (HFSCs) by enhancing PTEN expression, which in turn induced autophagy. This autophagy process was crucial for the differentiation of HFSCs, as evidenced by increased expression of epidermal and adipogenic markers and decreased expression of keratinocyte-specific and proliferation-related markers. The BMP2/PTEN axis also expedited wound contraction and epidermal regeneration in mice, highlighting its potential therapeutic applications in skin repair and regeneration.

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