PTEN Mediates Activation of Core Clock Protein BMAL1 and Accumulation of Epidermal Stem Cells

    June 2017 in “ Stem cell reports ”
    Chiara Zagni, Luciana O. Almeida, Tarek Balan … Cristiane H. Squarize
    Studysummary This study found that PTEN regulates the number and genomic stability of hair follicle stem cells in the skin, with its deficiency leading to increased stem cell accumulation and senescence through interactions with BMAL1 and BMI-1.
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    Research cited in this study 14

    1. Stem Cell Quiescence Acts as a Tumor Suppressor in Squamous Tumors Nature Cell Biology · 2013
    2. Local Circadian Clock Gates Cell Cycle Progression of Transient Amplifying Cells During Regenerative Hair Cycling Proceedings of the National Academy of Sciences of the United States of America · 2013
    3. Age-Associated Inflammation Inhibits Epidermal Stem Cell Function Genes & development · 2012
    4. Brain And Muscle Arnt-Like Protein-1 (BMAL1) Controls Circadian Cell Proliferation And Susceptibility To UVB-Induced DNA Damage In The Epidermis Proceedings of the National Academy of Sciences of the United States of America · 2012
    5. The Circadian Molecular Clock Creates Epidermal Stem Cell Heterogeneity Nature · 2011
    6. Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin Nature Reviews Molecular Cell Biology · 2009
    7. Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells Cell · 2008
    8. An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell Contribution ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2007
    9. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    10. BMP Signaling in the Control of Skin Development and Hair Follicle Growth Differentiation · 2004
    11. Defining BMP Functions in the Hair Follicle by Conditional Ablation of BMP Receptor IA The Journal of Cell Biology · 2003
    12. Hair Follicle Stem Cells: Insights from the 2003 Workshop ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2003
    13. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    14. Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin Genes & Development · 2001