Stem Cell Quiescence Acts as a Tumor Suppressor in Squamous Tumors

    December 2013 in “ Nature Cell Biology ”
    Andrew C. White, Joan Khuu, Christine Dang … William E. Lowry
    Studysummary This study found that quiescence in hair follicle stem cells acts as a tumor suppression mechanism for cutaneous squamous cell carcinoma, with Pten activity necessary to maintain this state.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on europepmc.org →
    Discuss this study in the Community →

    Research cited in this study 12

    1. Follicular Density and Ratios in Scarring and Nonscarring Alopecia The American Journal of Dermatopathology · 2013
    2. New Activators and Inhibitors in the Hair Cycle Clock: Targeting Stem Cells’ State of Competence Journal of Investigative Dermatology · 2012
    3. A Keratin 15 Containing Stem Cell Population From the Hair Follicle Contributes to Squamous Papilloma Development in the Mouse Molecular Carcinogenesis · 2012
    4. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    5. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    6. Basal Cell Carcinomas in Mice Arise from Hair Follicle Stem Cells and Multiple Epithelial Progenitor Populations Journal of Clinical Investigation · 2011
    7. Cutaneous Consequences of Inhibiting EGF Receptor Signaling In Vivo: Normal Hair Follicle Development, But Retarded Hair Cycle Induction and Inhibition of Adipocyte Growth in EgfrWa5 Mice Journal of Dermatological Science · 2010
    8. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    9. CD34 Expression by Hair Follicle Stem Cells Is Required for Skin Tumor Development in Mice Cancer Research · 2007
    10. Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion Stem Cells · 2006
    11. Defining the Impact of Beta-Catenin/Tcf Transactivation on Epithelial Stem Cells Genes & development · 2005
    12. Hair Follicle Stem Cells: Their Location, Role in Hair Cycle, and Involvement in Skin Tumor Formation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993