Stem Cell Quiescence Acts as a Tumor Suppressor in Squamous Tumors

December 2013 in “ Nature Cell Biology ”

Andrew C. White, Joan Khuu, Christine Dang, Jingtian Hu, K. V. Tran, A. Liu, Sobeyda Gomez, Z. Zhang, Rui Yi, Phillip Scumpia, Melina Grigorian, William E. Lowry

hair follicle stem cell HFSC quiescence cutaneous squamous cell carcinoma SCC tumor suppressor Pten KrasG12D telogen anagen p53 hyperplasia skin malignancies skin cancer resting phase growth phase skin tumors

Studysummary This study found that quiescence in hair follicle stem cells acts as a tumor suppression mechanism for cutaneous squamous cell carcinoma, with Pten activity necessary to maintain this state.

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