Defining Metabolic Flexibility in Hair Follicle Stem Cell Induced Squamous Cell Carcinoma

    October 2023 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    C. Galvan, Alex F. C. Flores, V Cerrillos, I. Avila, Colleen Murphy, Zheng Wang, TT To, Heather R. Christofk, William E. Lowry
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    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary In this study, researchers found that while blocking either glycolysis or glutaminolysis in cancer cells did not prevent tumor growth due to metabolic flexibility, simultaneous inhibition of both pathways hindered carcinoma development, indicating multiple interventions may be necessary for effective metabolic manipulation in cancer treatment.
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