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    Overexpression of Hypoxia-Inducible Factor-1α in Hidradenitis Suppurativa: The Link Between Deviated Immunity and Metabolism

    March 2023 in “ Archives of dermatological research ”
    Naglaa Agamia, Osama Ahmed Sorror, Naglaa Mohamed Sayed … Bodo C. Melnik
    Studysummary This study found that hidradenitis suppurativa is associated with increased serum levels of hypoxia-inducible factor-1α, suggesting its role in the disease's pathogenesis and as a treatment target.
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    Research cited in this study 8

    1. Human Hair Follicles Operate an Internal Cori Cycle and Modulate Their Growth via Glycogen Phosphorylase Scientific Reports · 2021
    2. Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis Suppurativa Frontiers in medicine · 2021
    3. Hidradenitis Suppurativa: A Folliculotropic Disease of Innate Immune Barrier Dysfunction? Experimental dermatology · 2021
    4. Hidradenitis Suppurativa Lesions Are Associated With Decreased Collagen, Decreased Elastin, And Increased Neovascularization Journal of Histotechnology · 2021
    5. What Causes Hidradenitis Suppurativa?—15 Years After Experimental Dermatology · 2020
    6. Hair Follicle Stem Cell Replication Stress Drives IFI16/STING-Dependent Inflammation in Hidradenitis Suppurativa Journal of Clinical Investigation · 2020
    7. T Helper 17 Cell/Regulatory T-Cell Imbalance in Hidradenitis Suppurativa/Acne Inversa: The Link to Hair Follicle Dissection, Obesity, Smoking, and Autoimmune Comorbidities British journal of dermatology/British journal of dermatology, Supplement · 2018
    8. Metabolism of Freshly Isolated Human Hair Follicles Capable of Hair Elongation: A Glutaminolytic, Aerobic Glycolytic Tissue Journal of Investigative Dermatology · 1993