Hidradenitis Suppurativa: A Folliculotropic Disease of Innate Immune Barrier Dysfunction?

    August 2021 in “ Experimental dermatology ”
    Daniel Johnston, Brian Kirby, Desmond J. Tobin
    Studysummary This review examines the dysregulation of innate immune barriers in the early stages of hidradenitis suppurativa and calls for further research on the role of the hair follicle and immune responses, but reports no new results.
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    Research cited in this study 13

    1. The Potential Relevance of the Microbiome to Hair Physiology and Regeneration: The Emerging Role of Metagenomics Biomedicines · 2021
    2. Histologic Progression of Acne Inversa/Hidradenitis Suppurativa: Implications for Future Investigations and Therapeutic Intervention Experimental dermatology · 2021
    3. What Causes Hidradenitis Suppurativa?—15 Years After Experimental Dermatology · 2020
    4. Hidradenitis Suppurativa as a Potential Subtype of Autoinflammatory Keratinization Disease Frontiers in immunology · 2020
    5. Hair Follicle Stem Cell Replication Stress Drives IFI16/STING-Dependent Inflammation in Hidradenitis Suppurativa Journal of Clinical Investigation · 2020
    6. Immune Cell Regulation of the Hair Cycle Experimental Dermatology · 2020
    7. The skin transcriptome in hidradenitis suppurativa uncovers an antimicrobial and sweat gland gene signature which has distinct overlap with wounded skin PLoS ONE · 2019
    8. Human αβ and γδ T Cells in Skin Immunity and Disease Frontiers in immunology · 2018
    9. The Follicular Skin Microbiome in Patients With Hidradenitis Suppurativa and Healthy Controls JAMA dermatology · 2017
    10. Deciphering the Functions of the Hair Follicle Infundibulum in Skin Physiology and Disease Cell and Tissue Research · 2014
    11. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    12. Open Questions in Hidradenitis Suppurativa Research: A Hair Biologist's Perspective Experimental dermatology · 2006
    13. The Genetically Programmed Hair Growth Cycle And Alopecia: What Is There To Know? Expert Review of Dermatology · 2006