Hidradenitis Suppurativa: A Folliculotropic Disease of Innate Immune Barrier Dysfunction?
August 2021
in “
Experimental dermatology
”
hidradenitis suppurativa hair follicle pilosebaceous unit sebaceous gland arrector pili muscle immune dysregulation inflammation innate immune cells pattern recognition receptors PRRs inflammasomes antimicrobial peptides AMPs skin barrier skin microbiome barrier immunity haired-skin barriers HS immune cells
TLDR Hidradenitis suppurativa is a skin disease caused by the breakdown of the skin's natural immune barriers, especially around hair follicles.
Hidradenitis suppurativa (HS) is a chronic skin disease characterized by inflammation and occlusion of the hair follicle, leading to skin inflammation. The disease's origins are thought to be in the pilosebaceous unit, which includes the hair follicle, sebaceous gland, and arrector pili muscle. The study suggests that HS is caused by a disturbance in the hair follicle, leading to immune dysregulation and inflammation. The study also discusses the role of innate immune cells, pattern recognition receptors (PRRs), and inflammasomes in HS. The expression of certain PRRs is elevated in HS, suggesting they may propagate inflammatory signaling in the disease. The study also highlights the dysregulated expression of antimicrobial peptides (AMPs) in HS, which may impact the relationship between the skin barrier and the skin microbiome. The document concludes that HS is likely initiated by alterations in barrier immunity, particularly in haired-skin barriers. Future treatments should aim to limit emerging inflammation and support barrier homeostasis and repair.
