What's New in Cicatricial Alopecia?

    January 2013 in “ Indian Journal of Dermatology, Venereology and Leprology ”
    Sunil Dogra, Rishu Sarangal
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    TLDR New treatments and early diagnosis methods for permanent hair loss due to scar tissue are important for managing its psychological effects.
    The document from 2013 reviews cicatricial alopecia (CA), particularly primary cicatricial alopecia (PCA), which is characterized by permanent hair loss due to the destruction of hair follicles and replacement by scar tissue. It classifies CA into different types based on the underlying inflammatory cells involved and suggests a stable versus unstable categorization for treatment decisions. The review discusses the pathogenesis of PCA, including autoimmune processes and the destruction of hair follicle stem cells, and considers genetic predisposition. It highlights the importance of early diagnosis using tools like dermoscopy and reflectance confocal microscopy, and the management of PCA through immunosuppression or antimicrobials depending on the type. New treatments such as PPARγ agonists and advances in surgical options like platelet-rich plasma therapies are mentioned. The document underscores the need for aggressive treatment to manage the psychosocial impact and calls for further research into the genetic and molecular mechanisms of PCA.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 7 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Losing Hair on Dutasteride? You might have LPP

      in Research/Science  94 upvotes 4 weeks ago
      Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.

      community You will lose hair if your prostaglandins aren't in balance

      in Research/Science  55 upvotes 1 week ago
      Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 2 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community Totally confused by doctors opinions, would appreciate some clarity

      in Treatment  1 upvotes 4 months ago
      The user is experiencing hair loss and confusion over conflicting medical advice, with treatments including minoxidil, finasteride, and topical corticosteroids. They are unsure about the necessity of a biopsy and the timing of using minoxidil, while also considering the impact of potential androgenetic alopecia and telogen effluvium.

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