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Glossary Immunosuppression

reduction of immune system activity or effectiveness

Immunosuppression, also known as immune suppression, refers to the reduction of the activation or efficacy of the immune system. This can be a deliberate process, such as when medications are used to prevent the body from rejecting a transplanted organ, or it can occur as a side effect of treatments like chemotherapy. It can also result from certain diseases that inherently weaken the immune response.

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Research

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research Immunosuppressive treatment for proliferative lupus nephritis

86 citations , June 2018 in “Cochrane library”

This review update suggests that mycophenolate mofetil may increase complete disease remission in proliferative lupus nephritis compared to intravenous cyclophosphamide, but with low certainty of evidence.

research Hair growth-stimulating effects of cyclosporin A and FK506, potent immunosuppressants

54 citations , July 1994 in “Journal of Dermatological Science”

This study found that topical application of FK506 stimulated hair growth in animals, which may occur independently of its immunosuppressive effects, though its effect on human hair growth remains unclear.

research Trichodysplasia of immunosuppression treated with oral valganciclovir

41 citations , December 2008 in “Journal of the American Academy of Dermatology”

This review discusses fixed drug eruption (FDE) potentially linked to finasteride and emphasizes dermatologists' need to recognize its possible occurrence due to the drug's widespread use, but reports no new clinical results.

research Viral-Associated Trichodysplasia of Immunosuppression

40 citations , August 2010 in “Archives of dermatology”

This case report describes the youngest known patient with viral-associated trichodysplasia of immunosuppression, where systemic valganciclovir therapy improved facial papule eruptions following cardiac transplantation.

research Effects of immunosuppressive peptidyl-prolyl cis-trans isomerase (PPIase) inhibitors, cyclosporin A, FK506, ascomycin and rapamycin, on hair growth initiation in mouse: immunosuppression is not required for new hair growth

20 citations , January 1995 in “Journal of Dermatological Science”

This study found that topical application of cyclosporin A and FK506 induces new hair growth in mice, while ascomycin and rapamycin do not, suggesting hair induction is not due to immunosuppression.

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community The DEFINITIVE cure for hairloss

285 upvotes 1 year ago

The conversation humorously suggests using immunosuppressants like ciclosporine and oral minoxidil for hair regrowth, with a satirical plan involving hair transplants from family members. It highlights the side effects and impracticality of such treatments, emphasizing the post's satirical nature.

community Upcoming treatment ideas in the future

11 upvotes 1 year ago

Exploring future hair loss treatments, including immunosuppressants for hair transplants and hair cloning, with a focus on leveraging research from other medical fields. Current treatments like finasteride and minoxidil are effective for most, but there's a call for more funding and innovation in the hair loss industry.

community OND-1 "Cyclosporine A” New hair loss treatment

in Research/Science 28 upvotes 5 months ago

Orient Bio is developing a PLGA formulated version of Cyclosporine A to stimulate hair growth without its immunosuppressant effects. Users discuss various treatments like Clascoterone, PP405, minoxidil, and tacrolimus, expressing hope for new developments and sharing personal experiences with these treatments.

community Making your own RT1640 in China

4 years ago

RT1640, a combination of cyclosporin A, minoxidil, and RT175, is discussed as a potential treatment for hair regrowth and repigmentation. The unique formulation aims to enhance hair follicle growth and restore hair pigment without the negative side effects of immunosuppressants.

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Learn

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learn Rapamycin

mTOR regulator and immunosuppressant used more recently for anti-aging and hair regrowth

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