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    Glossary Rapamycin

    drug that inhibits mTOR to suppress immune response

    Rapamycin, also known as Sirolimus, is a drug originally discovered in soil bacteria from Easter Island. It is primarily used as an immunosuppressant to prevent organ transplant rejection and has shown potential in extending lifespan and treating certain diseases by inhibiting a protein called mTOR, which regulates cell growth and metabolism.

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    1. Rapamycin Immune-suppressing drug, also called sirolimus

    Research 10 of 772

    1. Mammalian target of rapamycin complex 1 (mTORC1) may modulate the timing of anagen entry in mouse hair follicles Experimental dermatology · 2012 · 28 citations
    2. PKC downregulation upon rapamycin treatment attenuates mitochondrial disease Nature metabolism · 2020 · 26 citations
    3. Effects of immunosuppressive peptidyl-prolyl cis-trans isomerase (PPIase) inhibitors, cyclosporin A, FK506, ascomycin and rapamycin, on hair growth initiation in mouse: immunosuppression is not required for new hair growth Journal of Dermatological Science · 1995 · 20 citations
    4. Rapamycin but not acarbose decreases age-related loss of outer hair cells in the mouse Cochlea Hearing research · 2018 · 15 citations
    5. Efficacy and Safety of Sirolimus for Blue Rubber Bleb Nevus Syndrome: A Prospective Study ˜The œAmerican journal of gastroenterology · 2021 · 13 citations
    6. Fibrous Papule of the Face, Similar to Tuberous Sclerosis Complex-Associated Angiofibroma, Shows Activation of the Mammalian Target of Rapamycin Pathway: Evidence for a Novel Therapeutic Strategy? PLoS ONE · 2014 · 12 citations
    7. Promotion of Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigallocatechin Gallate Nanoparticles Pharmaceutics · 2022 · 7 citations
    8. Acne keloidalis nuchae in renal transplant patients receiving tacrolimus and sirolimus Australasian journal of dermatology · 2016 · 6 citations
    9. Protein kinase C is a key target for attenuation of Leigh syndrome by rapamycin bioRxiv (Cold Spring Harbor Laboratory) · 2019 · 5 citations
    10. Allogeneic Hair Transplantation with Enhanced Survival by Anti-ICAM-1 Antibody with Short-Term Rapamycin Treatment in Nonhuman Primates 2016 · 4 citations
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    Community 6

    1. A Novel Synergistic Strategy for Hair Loss Prevention and Reversal: Rapamycin, Finasteride, and Minoxidil Reddit · 7 Dec 2025
    2. Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigallocatechin Gallate Nanoparticles - PubMed Reddit · 21 Aug 2022
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