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GlossarymTORC2

protein complex regulating cell growth, survival, and metabolism

mTORC2, or mechanistic Target of Rapamycin Complex 2, is a protein complex that plays a crucial role in regulating cell growth, survival, and metabolism. It is part of the mTOR pathway, which is important for cellular responses to nutrients, growth factors, and stress, and has implications in conditions like cancer, diabetes, and aging.

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The Peptide AC 2 Isolated from Bacillus-Treated Trapa Japonica Fruit Extract Rescues DHT-Treated Human Dermal Papilla Cells and Mediates mTORC1 Signaling for Autophagy and Apoptosis Suppression

research The Peptide AC 2 Isolated from Bacillus-Treated Trapa Japonica Fruit Extract Rescues DHT-Treated Human Dermal Papilla Cells and Mediates mTORC1 Signaling for Autophagy and Apoptosis Suppression

9 citations , November 2019 in “Scientific reports”

The AC 2 peptide from Trapa japonica fruit helps protect hair cells and may treat hair loss.

research Impact of mTORC1 Inhibition on Keratinocyte Proliferation During Skin Tumor Promotion in Wild-Type and BK5.AktWT Mice

8 citations , September 2013 in “Molecular carcinogenesis”

Rapamycin reduces skin cell growth and tumor development by affecting cell signaling in mice.

research mTORC1 Activity Controls Human Scalp Hair Follicle Pigmentation and Growth

1 citations , April 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

mTORC1 activity is important for hair growth and color, and targeting it could help treat hair loss and greying.

research Topical Melatonin Unfolds Differential Anti-Aging Effects in Human Skin by Inhibiting mTORC1 Activity via TSC2 Stimulation

July 2024 in “Journal of Investigative Dermatology”

Topical melatonin may reduce skin aging by inhibiting certain cellular pathways.

research MTORC1 Activity Is Increased in the Skin of Acne Patients and Is Suppressed With Isotretinoin Treatment

April 2023 in “Journal of Investigative Dermatology”

Acne patients have higher skin mTORC1 activity, which is reduced by isotretinoin treatment.

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community [Nov 2019] The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression

21 upvotes 6 years ago

A peptide from Japanese water chestnut fruit may help with hair loss by suppressing DHT's effect on hair follicle cell death, potentially serving as a finasteride alternative. The treatment's effectiveness and safety in humans remain uncertain.

community A Novel Synergistic Strategy for Hair Loss Prevention and Reversal: Rapamycin, Finasteride, and Minoxidil

in Research/Science 39 upvotes 3 months ago

Rapamycin, finasteride, and minoxidil are discussed as a strategy for hair loss prevention and reversal. Pulsed dosing of rapamycin is suggested to avoid conflicting effects with minoxidil.

community How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.

in Research/Science 45 upvotes 1 year ago

ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.