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GlossarymTORC2

protein complex regulating cell growth, survival, and metabolism

mTORC2, or mechanistic Target of Rapamycin Complex 2, is a protein complex that plays a crucial role in regulating cell growth, survival, and metabolism. It is part of the mTOR pathway, which is important for cellular responses to nutrients, growth factors, and stress, and has implications in conditions like cancer, diabetes, and aging.

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research Characterization of Aberrant mTOR Signaling Pathway in U87MG Glioblastoma Cell Line by Quantitative Phosphoproteomics

January 2021

Inhibiting mTORC2 can reduce DNA repair and increase cancer cell death, suggesting potential for targeted brain cancer treatments.

research Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle

51 citations , September 2020 in “Cell Metabolism”

Glutamine metabolism affects hair stem cell maintenance and their ability to change back to stem cells.

research MTOR Signaling in Hair Follicle and Hair Diseases: Recent Progress

September 2023 in “Frontiers in medicine”

The mTOR signaling pathway is crucial for hair health and targeting it may lead to new hair loss treatments.

research Protein Kinase C Downregulation Upon Rapamycin Treatment Attenuates Neuroinflammation and Mitochondrial Disease

December 2020 in “Innovation in aging”

Rapamycin treatment helps reduce brain inflammation and symptoms of mitochondrial disease by blocking specific pathways in mice.

research Influence of Bovine Milk Oligosaccharides on Sebocyte Lipid Content and Inflammatory Mediators

April 2017 in “Journal of Investigative Dermatology”

Cow milk sugars increase fat production and inflammation in skin oil cells.

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community How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.

in Research/Science 45 upvotes 10 months ago

ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.