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    Glossary mTORC2

    protein complex regulating cell growth, survival, and metabolism

    mTORC2, or mechanistic Target of Rapamycin Complex 2, is a protein complex that plays a crucial role in regulating cell growth, survival, and metabolism. It is part of the mTOR pathway, which is important for cellular responses to nutrients, growth factors, and stress, and has implications in conditions like cancer, diabetes, and aging.

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    1. mTORC1 activity negatively regulates human hair follicle growth and pigmentation EMBO reports · 2023 · 12 citations
    2. Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild‐type and BK5.Akt<sup>WT</sup> mice Molecular carcinogenesis · 2013 · 8 citations
    3. Ozenoxacin suppresses sebum production by inhibiting mTORC1 activation in differentiated hamster sebocytes The Journal of Dermatology · 2024 · 6 citations
    4. Salvianolic acid B ameliorate alopecia by simultaneously targeting Wnt/β-catenin and mTORC2/Akt signaling Journal of Dermatological Science · 2026
    5. Mammalian target of rapamycin complex 1 (mTORC1) may modulate the timing of anagen entry in mouse hair follicles Experimental dermatology · 2012 · 28 citations
    6. Activation of mTORC1 Signaling is Required for Timely Hair Follicle Regeneration from Radiation Injury Radiation Research · 2017 · 12 citations
    7. The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression Scientific reports · 2019 · 9 citations
    8. 602 mTORC1 activity controls human scalp hair follicle pigmentation and growth 2021 · 1 citations
    9. 686 Topical melatonin unfolds differential anti-aging effects in human skin by inhibiting mTORC1 activity via TSC2 stimulation Journal of Investigative Dermatology · 2024
    10. 1370 MTORC1 activity is increased in the skin of acne patients and is suppressed with isotretinoin treatment Journal of Investigative Dermatology · 2023
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    1. [Nov 2019] The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression Reddit · 4 Dec 2019

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