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    Glossary mTORC1

    protein complex regulating cell growth and metabolism

    mTORC1, or mechanistic Target of Rapamycin Complex 1, is a protein complex that plays a crucial role in regulating cell growth, protein synthesis, and metabolism in response to nutrients and growth factors. It acts as a central hub for integrating signals from the environment to control cellular processes, making it essential for normal cell function and growth.

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    1. Mammalian target of rapamycin complex 1 (mTORC1) may modulate the timing of anagen entry in mouse hair follicles Experimental dermatology · 2012 · 28 citations
    2. mTORC1 activity negatively regulates human hair follicle growth and pigmentation EMBO reports · 2023 · 12 citations
    3. Activation of mTORC1 Signaling is Required for Timely Hair Follicle Regeneration from Radiation Injury Radiation Research · 2017 · 12 citations
    4. The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression Scientific reports · 2019 · 9 citations
    5. Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild‐type and BK5.Akt<sup>WT</sup> mice Molecular carcinogenesis · 2013 · 8 citations
    6. Ozenoxacin suppresses sebum production by inhibiting mTORC1 activation in differentiated hamster sebocytes The Journal of Dermatology · 2024 · 6 citations
    7. 602 mTORC1 activity controls human scalp hair follicle pigmentation and growth 2021 · 1 citations
    8. 686 Topical melatonin unfolds differential anti-aging effects in human skin by inhibiting mTORC1 activity via TSC2 stimulation Journal of Investigative Dermatology · 2024
    9. 1370 MTORC1 activity is increased in the skin of acne patients and is suppressed with isotretinoin treatment Journal of Investigative Dermatology · 2023
    10. 518 Nutrient and stress sensing as novel physiological regulator of human hair pigmentation and greying: Role of mTORC1 activity Journal of Investigative Dermatology · 2022
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    1. [Nov 2019] The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression Reddit · 4 Dec 2019

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