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    Glossary mTORC1

    protein complex regulating cell growth and metabolism

    mTORC1, or mechanistic Target of Rapamycin Complex 1, is a protein complex that plays a crucial role in regulating cell growth, protein synthesis, and metabolism in response to nutrients and growth factors. It acts as a central hub for integrating signals from the environment to control cellular processes, making it essential for normal cell function and growth.

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    Research 30 of 379

    1. Mammalian target of rapamycin complex 1 (mTORC1) may modulate the timing of anagen entry in mouse hair follicles Experimental dermatology · 2012 · 28 citations
    2. mTORC1 activity negatively regulates human hair follicle growth and pigmentation EMBO reports · 2023 · 12 citations
    3. Activation of mTORC1 Signaling is Required for Timely Hair Follicle Regeneration from Radiation Injury Radiation Research · 2017 · 12 citations
    4. The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression Scientific reports · 2019 · 9 citations
    5. Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild‐type and BK5.Akt<sup>WT</sup> mice Molecular carcinogenesis · 2013 · 8 citations
    6. Ozenoxacin suppresses sebum production by inhibiting mTORC1 activation in differentiated hamster sebocytes The Journal of Dermatology · 2024 · 6 citations
    7. 602 mTORC1 activity controls human scalp hair follicle pigmentation and growth 2021 · 1 citations
    8. 686 Topical melatonin unfolds differential anti-aging effects in human skin by inhibiting mTORC1 activity via TSC2 stimulation Journal of Investigative Dermatology · 2024
    9. 1370 MTORC1 activity is increased in the skin of acne patients and is suppressed with isotretinoin treatment Journal of Investigative Dermatology · 2023
    10. 518 Nutrient and stress sensing as novel physiological regulator of human hair pigmentation and greying: Role of mTORC1 activity Journal of Investigative Dermatology · 2022
    11. 650 Controlling mTORC1 activity as a novel therapeutic strategy for managing human hair growth and pigmentation 2022
    12. Abstract 5357: Targeting mTORC1 suppresses proliferation of keratinocyte stem cells and inhibits skin tumor promotion in mice Cancer research · 2014
    13. Abstract 2559: Targeting mTORC1 may provide selectivity for inhibiting proliferation of hair follicle stem/progenitor cells during tumor promotion Cancer research · 2012
    14. Salvianolic acid B ameliorate alopecia by simultaneously targeting Wnt/β-catenin and mTORC2/Akt signaling Journal of Dermatological Science · 2026
    15. The complex relationship between TFEB transcription factor phosphorylation and subcellular localization EMBO journal · 2018 · 344 citations
    16. Linking diet to acne metabolomics, inflammation, and comedogenesis: an update Clinical, Cosmetic and Investigational Dermatology · 2015 · 138 citations
    17. Mechanistic target of rapamycin (mTOR) expression is increased in acne patients' skin Experimental Dermatology · 2015 · 74 citations
    18. Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion PloS one · 2012 · 72 citations
    19. mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration 2015 · 71 citations
    20. Overactivated sonic hedgehog signaling aggravates intrauterine adhesion via inhibiting autophagy in endometrial stromal cells Cell Death and Disease · 2020 · 52 citations
    21. Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle Cell Metabolism · 2020 · 51 citations
    22. Human TSC2-null fibroblast-like cells induce hair follicle neogenesis and hamartoma morphogenesis Nature Communications · 2011 · 36 citations
    23. Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation Journal of Allergy and Clinical Immunology · 2019 · 34 citations
    24. Human Hair Graying Revisited: Principles, Misconceptions, and Key Research Frontiers Journal of Investigative Dermatology · 2023 · 21 citations
    25. Melatonin Exerts Prominent, Differential Epidermal and Dermal Anti-Aging Properties in Aged Human Eyelid Skin Ex Vivo International Journal of Molecular Sciences · 2023 · 21 citations
    26. ADM Scaffolds Generate a Pro-regenerative Microenvironment During Full-Thickness Cutaneous Wound Healing Through M2 Macrophage Polarization via Lamtor1 Frontiers in Physiology · 2018 · 17 citations
    27. Stem Cells on Alert: Priming Quiescent Stem Cells after Remote Injury Cell stem cell · 2014 · 13 citations
    28. Establishment of Tsc2-deficient rat embryonic stem cells International Journal of Oncology · 2015 · 8 citations
    29. A Review of the Impact of Calorie Restriction on Stem Cell Potency 2021 · 4 citations
    30. What’s Diet Got to Do With It? Basic and Clinical Science Behind Diet and Acne Cutis · 2022 · 2 citations