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    Glossary mTORC2

    protein complex regulating cell growth, survival, and metabolism

    mTORC2, or mechanistic Target of Rapamycin Complex 2, is a protein complex that plays a crucial role in regulating cell growth, survival, and metabolism. It is part of the mTOR pathway, which is important for cellular responses to nutrients, growth factors, and stress, and has implications in conditions like cancer, diabetes, and aging.

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    Research 30 of 392

    1. mTORC1 activity negatively regulates human hair follicle growth and pigmentation EMBO reports · 2023 · 12 citations
    2. Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild‐type and BK5.Akt<sup>WT</sup> mice Molecular carcinogenesis · 2013 · 8 citations
    3. Ozenoxacin suppresses sebum production by inhibiting mTORC1 activation in differentiated hamster sebocytes The Journal of Dermatology · 2024 · 6 citations
    4. Salvianolic acid B ameliorate alopecia by simultaneously targeting Wnt/β-catenin and mTORC2/Akt signaling Journal of Dermatological Science · 2026
    5. Mammalian target of rapamycin complex 1 (mTORC1) may modulate the timing of anagen entry in mouse hair follicles Experimental dermatology · 2012 · 28 citations
    6. Activation of mTORC1 Signaling is Required for Timely Hair Follicle Regeneration from Radiation Injury Radiation Research · 2017 · 12 citations
    7. The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression Scientific reports · 2019 · 9 citations
    8. 602 mTORC1 activity controls human scalp hair follicle pigmentation and growth 2021 · 1 citations
    9. 686 Topical melatonin unfolds differential anti-aging effects in human skin by inhibiting mTORC1 activity via TSC2 stimulation Journal of Investigative Dermatology · 2024
    10. 1370 MTORC1 activity is increased in the skin of acne patients and is suppressed with isotretinoin treatment Journal of Investigative Dermatology · 2023
    11. 518 Nutrient and stress sensing as novel physiological regulator of human hair pigmentation and greying: Role of mTORC1 activity Journal of Investigative Dermatology · 2022
    12. 650 Controlling mTORC1 activity as a novel therapeutic strategy for managing human hair growth and pigmentation 2022
    13. Abstract 5357: Targeting mTORC1 suppresses proliferation of keratinocyte stem cells and inhibits skin tumor promotion in mice Cancer research · 2014
    14. Abstract 2559: Targeting mTORC1 may provide selectivity for inhibiting proliferation of hair follicle stem/progenitor cells during tumor promotion Cancer research · 2012
    15. The complex relationship between TFEB transcription factor phosphorylation and subcellular localization EMBO journal · 2018 · 344 citations
    16. Linking diet to acne metabolomics, inflammation, and comedogenesis: an update Clinical, Cosmetic and Investigational Dermatology · 2015 · 138 citations
    17. Mechanistic target of rapamycin (mTOR) expression is increased in acne patients' skin Experimental Dermatology · 2015 · 74 citations
    18. Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion PloS one · 2012 · 72 citations
    19. mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration 2015 · 71 citations
    20. Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle Cell Metabolism · 2020 · 51 citations
    21. Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation Journal of Allergy and Clinical Immunology · 2019 · 34 citations
    22. Stem Cells on Alert: Priming Quiescent Stem Cells after Remote Injury Cell stem cell · 2014 · 13 citations
    23. What’s Diet Got to Do With It? Basic and Clinical Science Behind Diet and Acne Cutis · 2022 · 2 citations
    24. mTOR signaling in hair follicle and hair diseases: recent progress Frontiers in medicine · 2023
    25. Protein Kinase C Downregulation upon Rapamycin Treatment Attenuates Neuroinflammation and Mitochondrial Disease Innovation in aging · 2020
    26. 878 Influence of bovine milk oligosaccharides on sebocyte lipid content and inflammatory mediators Journal of Investigative Dermatology · 2017
    27. Overactivated sonic hedgehog signaling aggravates intrauterine adhesion via inhibiting autophagy in endometrial stromal cells Cell Death and Disease · 2020 · 52 citations
    28. Human TSC2-null fibroblast-like cells induce hair follicle neogenesis and hamartoma morphogenesis Nature Communications · 2011 · 36 citations
    29. Human Hair Graying Revisited: Principles, Misconceptions, and Key Research Frontiers Journal of Investigative Dermatology · 2023 · 21 citations
    30. Melatonin Exerts Prominent, Differential Epidermal and Dermal Anti-Aging Properties in Aged Human Eyelid Skin Ex Vivo International Journal of Molecular Sciences · 2023 · 21 citations