TLDR A protein complex called mTORC1 likely affects when hair growth starts in mice.
The study on C57BL/6J mice found that mTORC1 activity was high during the anagen phase and low during telogen, suggesting its role in hair follicle proliferation. Immunohistochemical analysis indicated mTOR activation in the bulge region during late telogen, potentially initiating anagen. Treatment with the mTORC1 inhibitor rapamycin delayed anagen onset, supporting mTORC1's role in modulating hair growth timing. The study concluded that mTORC1 might influence the timing of anagen initiation in hair follicles.
835 citations,
October 2008 in “Nature Genetics” Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.
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November 2000 in “Proceedings of the National Academy of Sciences of the United States of America” There are two ways to start hair growth: one needs Stat3 and the other does not, but both need PI3K activation.
271 citations,
March 1999 in “Developmental biology” The research shows that a gene called Wnt3 affects hair growth and structure, causing short hair and balding when overactive.
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February 1999 in “The journal of investigative dermatology/Journal of investigative dermatology” IGF-1 increases whisker growth in transgenic mice.
130 citations,
January 1994 in “Differentiation” Mouse hair follicle cells briefly grow during the early hair growth phase, showing that these cells are important for starting the hair cycle.
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January 1951 in “Physiological zoology” Hair growth and pigmentation in mice involve specific stages crucial for research.
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May 2016 in “Experimental and Therapeutic Medicine” MMP-2 and MMP-9 help hair grow, while their inhibitors peak when hair growth slows.
April 2016 in “Journal of Investigative Dermatology” Wnt ligands, produced by dermal papilla cells, are essential for adult hair growth and regeneration.