Mammalian Target of Rapamycin Complex 1 (mTORC1) May Modulate the Timing of Anagen Entry in Mouse Hair Follicles

November 2012 in “ Experimental dermatology ”

Antonia J. Kellenberger, Miyuki Tauchi

mTORC1 anagen phase telogen phase hair follicle proliferation immunohistochemical analysis bulge region rapamycin mTOR activation mTOR hair growth phase hair rest phase hair growth IHC hair follicle bulge sirolimus

TLDR A protein complex called mTORC1 likely affects when hair growth starts in mice.

The study on C57BL/6J mice found that mTORC1 activity was high during the anagen phase and low during telogen, suggesting its role in hair follicle proliferation. Immunohistochemical analysis indicated mTOR activation in the bulge region during late telogen, potentially initiating anagen. Treatment with the mTORC1 inhibitor rapamycin delayed anagen onset, supporting mTORC1's role in modulating hair growth timing. The study concluded that mTORC1 might influence the timing of anagen initiation in hair follicles.

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