TLDR There are two ways to start hair growth: one needs Stat3 and the other does not, but both need PI3K activation.
The study identified two distinct signaling pathways involved in hair cycle induction in mice: a Stat3-dependent pathway crucial for spontaneous anagen progression and a Stat3-independent (likely PKC-dependent) pathway for hair regrowth induced by external stimuli like PMA application or hair plucking. Stat3-disrupted mice exhibited delayed anagen onset and reduced hair growth, but anagen could still be induced through chemical or mechanical stimulation, indicating that hair growth stimuli could bypass the Stat3 pathway. Both pathways required PI3K activation for keratinocyte migration, highlighting the complexity of hair growth regulation.
90 citations,
October 1996 in “Dermatologic Clinics” Growth factors are crucial for hair development and could help treat hair diseases.
114 citations,
October 1996 in “Dermatologic clinics” Hair loss is mainly caused by hormones, autoimmune issues, and chemotherapy, and needs more research for treatments.
130 citations,
January 1994 in “Differentiation” Mouse hair follicle cells briefly grow during the early hair growth phase, showing that these cells are important for starting the hair cycle.
578 citations,
April 1993 in “Cell” TGFα gene mutation in mice causes abnormal skin, wavy hair, curly whiskers, and sometimes eye inflammation.
745 citations,
February 1992 in “Trends in genetics” Hair follicles create different cell layers and proteins, controlled by various molecules.
21 citations,
May 2022 in “Frontiers in Cell and Developmental Biology” Hair growth and health are influenced by factors like age, environment, and nutrition, and are controlled by various molecular pathways. Red light can promote hair growth, and understanding these processes can help treat hair-related diseases.
21 citations,
May 2016 in “Experimental and Therapeutic Medicine” MMP-2 and MMP-9 help hair grow, while their inhibitors peak when hair growth slows.
224 citations,
March 2006 in “Seminars in Cutaneous Medicine and Surgery” The document concludes that understanding hair follicle biology can lead to better hair loss treatments.
