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GlossaryRapamycin (Sirolimus)

drug that inhibits mTOR to suppress immune response

Rapamycin, also known as Sirolimus, is a drug originally discovered in soil bacteria from Easter Island. It is primarily used as an immunosuppressant to prevent organ transplant rejection and has shown potential in extending lifespan and treating certain diseases by inhibiting a protein called mTOR, which regulates cell growth and metabolism.

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learn Rapamycin

mTOR regulator and immunosuppressant used more recently for anti-aging and hair regrowth

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research Efficacy and Safety of Sirolimus for Blue Rubber Bleb Nevus Syndrome: A Prospective Study

13 citations, January 2021 in “The American journal of gastroenterology”

Sirolimus effectively reduces lesions and improves quality of life in Blue Rubber Bleb Nevus Syndrome with manageable side effects.

research Acne Keloidalis Nuchae in Renal Transplant Patients Receiving Tacrolimus and Sirolimus

6 citations, April 2016 in “Australasian journal of dermatology”

Renal transplant patients on tacrolimus and sirolimus may develop acne keloidalis nuchae.

research Understanding Cellular and Molecular Responses in the Treatment of Pediatric Lymphatic Anomalies

April 2017 in “Journal of Investigative Dermatology”

Sirolimus and propranolol may reduce abnormal cell growth and improve lymphatic malformations in children.

research Editors' Picks

October 2013 in “Journal of Investigative Dermatology”

Collagen VII helps skin heal and stay strong, sirolimus may lower skin cancer risk in kidney transplant patients, high-molecular-mass hyaluronan helps naked mole rats resist cancer, dermal γδ T cells aid in hair growth in rodents, and overexpression of IL-33 in mouse skin causes itchiness, offering a model for studying allergic inflammation treatments.

research Cutaneous Toxicities From Transplantation-Related Medications

14 citations, April 2017 in “American Journal of Transplantation”

Skin problems from transplant drugs are common and need careful management in organ transplant patients.

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