Increased Vibrissa Growth in Transgenic Mice Expressing Insulin-Like Growth Factor 1

February 1999 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

Hexiu Su, Jonathan G. H. Hickford, Pauline H.B. The, Anne M. Hill, R. Bickerstaffe, Chris Frampton

insulin-like growth factor 1 IGF-1 hair follicles epithelial cell proliferation follicle bulb IGF-1

Studysummary In this study, researchers found that overexpression of IGF-1 in transgenic mice stimulated increased vibrissa growth during the first neonatal hair cycle compared to their nontransgenic littermates.

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The study investigated the effects of local overexpression of insulin-like growth factor 1 (IGF-1) on vibrissa (whisker) growth in transgenic mice. Transgenic mice expressing the IGF-1 transgene showed a significant increase in vibrissa length compared to nontransgenic mice, with a 20.5% increase during days 11-16 and an 11.9% increase during days 16-21. The results demonstrated that local IGF-1 production in hair follicles could enhance vibrissa growth through paracrine effects on epithelial cell proliferation in the follicle bulb, without affecting systemic IGF-1 levels or body weight.

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research Overexpression of Insulin-Like Growth Factor-1 Induces Hyperplasia, Dermal Abnormalities, and Spontaneous Tumor Formation in Transgenic Mice

147 citations , April 1997 in “Oncogene”

This study found that transgenic mice expressing IGF-1 in their skin showed significant skin changes, early hair follicle generation, and a higher propensity to develop tumors after chemical promotion, suggesting IGF-1's role in skin carcinogenesis.

research The Insulin-Like Growth Factor 1 Receptor Is Expressed by Epithelial Cells with Proliferative Potential in Human Epidermis and Skin Appendages: Correlation of Increased Expression with Epidermal Hyperplasia

128 citations , March 1996 in “Journal of Investigative Dermatology”

Increased IGF-1R expression is linked to thicker skin growth.

research Hair-Specific Expression of Chloramphenicol Acetyltransferase in Transgenic Mice Under the Control of an Ultra-High-Sulfur Keratin Promoter

33 citations , September 1990 in “Proceedings of the National Academy of Sciences”

This study found that a 671-base pair promoter sequence from the ultra-high-sulfur keratin gene is sufficient to direct tissue-specific and development-specific expression of a reporter gene during hair growth in transgenic mice.