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    Glossary mTOR

    regulates cell growth and metabolism in response to nutrients

    mTOR, or the mechanistic target of rapamycin, is a protein that acts as a central regulator of cell growth, proliferation, and survival. It integrates signals from nutrients, growth factors, and cellular energy status to control processes like protein synthesis and autophagy. This pathway is significant in various biological contexts, including hair growth and alopecia, as it influences the activity of hair follicle cells.

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    1. Folliculin encoded by the <i>BHD</i> gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling Proceedings of the National Academy of Sciences · 2006 · 475 citations
    2. Mechanistic target of rapamycin (mTOR) expression is increased in acne patients' skin Experimental Dermatology · 2015 · 74 citations
    3. mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration 2015 · 71 citations
    4. Molecular Genetics of the PI3K-AKT-mTOR Pathway in Genodermatoses: Diagnostic Implications and Treatment Opportunities 2016 · 36 citations
    5. The regulation of skin homeostasis, repair and the pathogenesis of skin diseases by spatiotemporal activation of epidermal mTOR signaling Frontiers in Cell and Developmental Biology · 2022 · 35 citations
    6. Mammalian target of rapamycin complex 1 (mTORC1) may modulate the timing of anagen entry in mouse hair follicles Experimental dermatology · 2012 · 28 citations
    7. Sesn2/AMPK/mTOR signaling mediates balance between survival and apoptosis in sensory hair cells under stress Cell death and disease · 2017 · 21 citations
    8. Promoting axonal regeneration through exosomes: An update of recent findings on exosomal PTEN and mTOR modifiers Brain Research Bulletin · 2018 · 14 citations
    9. mTORC1 activity negatively regulates human hair follicle growth and pigmentation EMBO reports · 2023 · 12 citations
    10. Activation of mTORC1 Signaling is Required for Timely Hair Follicle Regeneration from Radiation Injury Radiation Research · 2017 · 12 citations
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    1. [Nov 2019] The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression Reddit · 4 Dec 2019
    2. New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase Reddit · 22 May 2024

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