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Glossary mTOR pathway

regulates cell growth and metabolism in response to nutrients

The mTOR pathway, short for the mechanistic target of rapamycin pathway, is a crucial cellular signaling pathway that regulates growth, metabolism, and survival in response to nutrients, growth factors, and other environmental cues. It plays a significant role in various biological processes, including cell proliferation, protein synthesis, and autophagy, and is implicated in conditions like cancer, diabetes, and neurodegenerative diseases.

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Research

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research 896 Androgens activate lipogenesis through an AKT-independent mTOR pathway stimulation and a limitation of autophagy in an androgen-sensitive sebocyte cell line

April 2019 in “Journal of Investigative Dermatology”

This study demonstrates that DHT-induced lipid synthesis in sebocytes involves the mTOR pathway, suggesting mTOR inhibitors may help modulate androgen-dependent sebum overproduction.

research 1341 Possible role of mTOR signaling pathway in radiation dermatitis

April 2023 in “Journal of Investigative Dermatology”

This study suggests that the mTOR signaling pathway may play a role in the pathophysiology of radiation dermatitis, with expression patterns of S6K1 protein differing from those in normal and inflamed skin.

research Cepharanthine Inhibits Doxorubicin-Induced Cellular Senescence by Activating Autophagy via the mTOR Signaling Pathway

January 2023 in “Discovery medicine”

This study found that Cepharanthine may mitigate doxorubicin-induced senescence by reducing SA-β-Gal activity and restoring autophagy in cell models, offering insights for antiaging drug development.

research Molecular Genetics of the PI3K-AKT-mTOR Pathway in Genodermatoses: Diagnostic Implications and Treatment Opportunities

36 citations , January 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

This article reviews the connection between PI3K-AKT-mTOR pathway mutations and heritable skin diseases characterized by tissue overgrowth, but it reports no new clinical results.

research Differential expression of mTOR signaling pathway proteins in lichen planopilaris and frontal fibrosing alopecia

5 citations , September 2018 in “Acta histochemica”

This study observed that proteins in the mTOR signaling pathway are expressed differently in the hair follicles of patients with lichen planopilaris and frontal fibrosing alopecia, suggesting a role in the pathogenesis of these conditions.

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learn Rapamycin

mTOR regulator and immunosuppressant used more recently for anti-aging and hair regrowth

What is rapamycin, and how is it being studied as a potential treatment for hair loss? Rapamycin is being studied for hair loss due to its effects on the mTOR pathway.

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Community Join

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community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

121 upvotes 2 years ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community I Guess balding is cured so should we close subreddit and move to hairstyling photos 😁 Botox-like nerve blocking reveals potential way to fully regenerate skin without scarring

6 months ago

Baldness is difficult to cure because current treatments like finasteride, dutasteride, and minoxidil only prevent hair shedding, and new developments are mostly ineffective. Botox shows potential in aiding skin regeneration and hair growth, but maintenance therapy with treatments like dutasteride and minoxidil may still be necessary.

community Success using NMN and quercetin.

6 upvotes 3 years ago

OP experienced hair improvement using NMN and quercetin after stopping finasteride, but later resumed finasteride due to shedding. They believe NMN and quercetin still help with hair loss.

community TCA 35% chemical peel, don't try this shit at home.

11 upvotes 7 months ago

The conversation discusses using a TCA 35% chemical peel on the scalp to potentially improve hair growth by addressing fibrosis and enhancing the effectiveness of topical treatments. The user also mentions trying microneedling and other methods like topical metformin and dutasteride for hair regrowth.

community Fats on your Head to Stop Hair Loss?

140 upvotes 2 years ago

The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

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