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    Glossary mTOR pathway

    regulates cell growth and metabolism in response to nutrients

    The mTOR pathway, short for the mechanistic target of rapamycin pathway, is a crucial cellular signaling pathway that regulates growth, metabolism, and survival in response to nutrients, growth factors, and other environmental cues. It plays a significant role in various biological processes, including cell proliferation, protein synthesis, and autophagy, and is implicated in conditions like cancer, diabetes, and neurodegenerative diseases.

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    1. 896 Androgens activate lipogenesis through an AKT-independent mTOR pathway stimulation and a limitation of autophagy in an androgen-sensitive sebocyte cell line Journal of Investigative Dermatology · 2019
    2. 1341 Possible role of mTOR signaling pathway in radiation dermatitis Journal of Investigative Dermatology · 2023
    3. Cepharanthine Inhibits Doxorubicin-Induced Cellular Senescence by Activating Autophagy via the mTOR Signaling Pathway Discovery medicine · 2023
    4. Molecular Genetics of the PI3K-AKT-mTOR Pathway in Genodermatoses: Diagnostic Implications and Treatment Opportunities 2016 · 36 citations
    5. Differential expression of mTOR signaling pathway proteins in lichen planopilaris and frontal fibrosing alopecia Acta histochemica · 2018 · 5 citations
    6. The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds Cells · 2023 · 9 citations
    7. Characterization of aberrant mTOR signaling pathway in U87MG glioblastoma cell line by quantitative phosphoproteomics 2021
    8. Stimulation by exosomes from hypoxia-preconditioned hair follicle mesenchymal stem cells facilitates mitophagy by inhibiting the PI3K/AKT/mTOR signaling pathway to alleviate ulcerative colitis Theranostics · 2024
    9. Molecular pathways involved in hair follicle tumor formation: all about mammalian target of rapamycin? Experimental Dermatology · 2009 · 18 citations
    10. Fibrous Papule of the Face, Similar to Tuberous Sclerosis Complex-Associated Angiofibroma, Shows Activation of the Mammalian Target of Rapamycin Pathway: Evidence for a Novel Therapeutic Strategy? PLoS ONE · 2014 · 12 citations
    11. Differential expression of phospho‐S6 in hair follicle tumors: Evidence of mammalian target of rapamycin pathway activation Journal of cutaneous pathology · 2019 · 4 citations
    12. 0843 N6-methyladenosine RNA modification promotes keratinocyte proliferation and cutaneous wound repair through regulation of MTOR stability Journal of Investigative Dermatology · 2025 · 1 citations
    13. Role of UVA-driven cellular senescence via mTOR activation in dihydrotestosterone-induced hair loss in androgenetic alopecia mouse model Journal of Photochemistry and Photobiology B Biology · 2025
    14. 976 Knockout of mTOR/Akt inhibitor REDD1 results in hair cycle-independent dermal adipose expansion by promoting adipocyte differentiation Journal of Investigative Dermatology · 2019
    15. mTOR signaling in hair follicle and hair diseases: recent progress Frontiers in medicine · 2023
    16. ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change Journal of experimental botany · 2013 · 161 citations
    17. New insights into molecular signaling pathways and current advancements in prostate cancer diagnostics & therapeutics Frontiers in Oncology · 2023
    18. Valproic acid boosts hair follicle stem cell resilience to oxygen-glucose deprivation through autophagy induction and AKT/mTOR suppression Scientific Reports · 2025
    19. Calcineurin/Nuclear Factor of Activated T-Cell Pathway in Cutaneous Squamous Cell Carcinoma International journal of dermatology and venereology · 2019
    20. Immunohistochemical Analysis of the Mechanistic Target of Rapamycin and Hypoxia Signalling Pathways in Basal Cell Carcinoma and Trichoepithelioma PloS one · 2014 · 15 citations
    21. Comparative Transcriptome Analysis of the Regenerating Zebrafish Telencephalon Unravels a Resource With Key Pathways During Two Early Stages and Activation of Wnt/β-Catenin Signaling at the Early Wound Healing Stage Frontiers in Cell and Developmental Biology · 2020 · 33 citations
    22. Effective amelioration of hepatic inflammation and insulin response in high fat diet-fed rats via regulating AKT/mTOR signaling: Role of Lepidium sativum seed extracts Journal of ethnopharmacology · 2020 · 14 citations
    23. Low-Molecular-Weight Fish Collagen Peptide Enhances Hair Regrowth via Activation of Proliferative Signaling and Suppression of Inhibitory Pathways Marine Drugs · 2026
    24. Aging and Immortality: Quasi-Programmed Senescence and Its Pharmacologic Inhibition Cell Cycle · 2006 · 295 citations
    25. Birt–Hogg–Dubé syndrome: from gene discovery to molecularly targeted therapies Familial cancer · 2012 · 39 citations
    26. Hair curvature: a natural dialectic and review 2014 · 28 citations
    27. Heat stress decreased hair follicle population in rex rabbits Journal of animal physiology and animal nutrition · 2018 · 10 citations
    28. Birt–Hogg–Dubé syndrome Familial cancer · 2013 · 7 citations
    29. Discovery and Functional Analysis of Secondary Hair Follicle miRNAs during Annual Cashmere Growth International journal of molecular sciences · 2023 · 3 citations
    30. Long-Term Effects of Sirolimus on Human Skin TSC2-Null Fibroblast‒Like Cells Journal of Investigative Dermatology · 2021 · 1 citations