Hair Curvature: A Natural Dialectic and Review

March 2014 in “ Biological reviews/Biological reviews of the Cambridge Philosophical Society ”

J. Nissimov, Amala Chaudhuri

TLDR The document concludes that hair curvature can be explained by the growth patterns caused by the shape and separation of cells in the hair follicle and is affected by specific molecular pathways.

The article explored the genetic and physical mechanisms behind hair curvature, proposing a multiple papillary centres (MPC) model to explain hair twisting. This model suggested that differential growth rates in hair cortical material, induced by partially or completely separated dermal papillae within single follicles, could account for various hair forms. The study reviewed evidence supporting the involvement of the Wnt and mTOR pathways in hair bending and twisting, respectively. It also considered epithelial-to-mesenchymal (EMT) and mesenchymal-to-epithelial (MET) transitions as mechanisms influencing hair growth and morphology. The MPC model aimed to provide a unified framework for understanding hair growth and development from neural-crest stem cell (NCSC) lineages to differentiated hair follicle (HF) cell types.

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