Hair Curvature: A Natural Dialectic and Review

    J. Nissimov, Amala Chaudhuri
    Studysummary This study introduces the multiple papillary centres model, offering a new explanation for hair twisting by combining known hair morphology features with differential growth rates caused by dermal papillae.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on doi.org →
    Discuss this study in the Community →

    Research cited in this study 130

    1. Dihydrotestosterone Inhibits Hair Growth in Mice by Inhibiting Insulin-Like Growth Factor-I Production in Dermal Papillae Growth Hormone & IGF Research · 2024
    2. Diseases That Turn African Hair Silky International Journal of Dermatology · 2012
    3. Scalable Production of Controllable Dermal Papilla Spheroids on PVA Surfaces and the Effects of Spheroid Size on Hair Follicle Regeneration Biomaterials · 2012
    4. Morphogenesis of Chimeric Hair Follicles in Engineered Skin Substitutes With Human Keratinocytes and Murine Dermal Papilla Cells Experimental Dermatology · 2012
    5. Tissue-Selective Regulation of Androgen-Responsive Genes Endocrine Research · 2012
    6. Polyclonal Origin and Hair Induction Ability of Dermal Papillae in Neonatal and Adult Mouse Back Skin Developmental Biology · 2012
    7. A Function for Rac1 in the Terminal Differentiation and Pigmentation of Hair Journal of cell science · 2012
    8. Proteomic Tools for the Investigation of Human Hair Structural Proteins and Evidence of Weakness Sites on Hair Keratin Coil Segments Analytical biochemistry · 2011
    9. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    10. Clonal Multipotency and Effect of Long-Term In Vitro Expansion on Differentiation Potential of Human Hair Follicle Derived Mesenchymal Stem Cells Stem Cell Research · 2011
    11. Human TSC2-Null Fibroblast-Like Cells Induce Hair Follicle Neogenesis and Hamartoma Morphogenesis Nature Communications · 2011
    12. EZH1 and EZH2 Co-Govern Histone H3K27 Trimethylation and Are Essential for Hair Follicle Homeostasis and Wound Repair Genes & Development · 2011
    13. The Basement Membrane Of Hair Follicle Stem Cells Is A Muscle Cell Niche Cell · 2011
    14. The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target During Hair Follicle and Nail Differentiation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2010
    15. Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla Journal of Dermatological Science · 2010
    16. The Naked Truth: Sphynx and Devon Rex Cat Breed Mutations in KRT71 Mammalian genome · 2010
    17. De Novo Production of Dermal Papilla Cells During the Anagen Phase of the Hair Cycle Journal of Investigative Dermatology · 2010
    18. Bimatoprost in the Treatment of Eyelash Hypotrichosis Clinical ophthalmology · 2010
    19. Autosomal-Dominant Woolly Hair Resulting from Disruption of Keratin 74, a Potential Determinant of Human Hair Texture The American Journal of Human Genetics · 2010
    20. A Mouse Model of Androgenetic Alopecia Endocrinology · 2010
    21. Identification of Transcriptional Targets of Wnt/β-Catenin Signaling in Dermal Papilla Cells of Human Scalp Hair Follicles: EP2 Is a Novel Transcriptional Target of Wnt3a Journal of Dermatological Science · 2010
    22. Human Dermal Stem Cells Differentiate Into Functional Epidermal Melanocytes Journal of Cell Science · 2010
    23. Neural Wiskott-Aldrich Syndrome Protein Modulates Wnt Signaling and Is Required for Hair Follicle Cycling in Mice Journal of Clinical Investigation · 2010
    24. Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion Biomedical research · 2010
    25. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    26. Common Variants in the Trichohyalin Gene Are Associated with Straight Hair in Europeans American journal of human genetics · 2009
    27. Sox2-Positive Dermal Papilla Cells Specify Hair Follicle Type in Mammalian Epidermis Development · 2009
    28. FGFR2 Is Associated With Hair Thickness In Asian Populations Journal of human genetics · 2009
    29. The Keratins of the Human Beard Hair Medulla: The Riddle in the Middle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2009
    30. From Telogen to Exogen: Mechanisms Underlying Formation and Subsequent Loss of the Hair Club Fiber Journal of Investigative Dermatology · 2009
    31. Ectodysplasin Signaling in Cutaneous Appendage Development: Dose, Duration, and Diversity ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2009
    32. TGF-β2 Is Specifically Expressed in Human Dermal Papilla Cells and Modulates Hair Folliculogenesis Journal of Cellular and Molecular Medicine · 2009
    33. Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin ˜The œAmerican journal of pathology · 2009
    34. Keratinocyte Growth Inhibition Through the Modification of Wnt Signaling by Androgen in Balding Dermal Papilla Cells ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2009
    35. Molecular Pathways Involved in Hair Follicle Tumor Formation: All About Mammalian Target of Rapamycin? Experimental Dermatology · 2009
    36. Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis Nature Genetics · 2009
    37. Cortical Cell Types and Intermediate Filament Arrangements Correlate with Fiber Curvature in Japanese Human Hair Journal of structural biology · 2008
    38. Genetic Interplays Between Msx2 And Foxn1 Are Required For Notch1 Expression And Hair Shaft Differentiation Developmental Biology · 2008
    39. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    40. Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation The Journal of Clinical Endocrinology & Metabolism · 2008
    41. Transglutaminase-3 Enzyme: A Putative Actor in Human Hair Shaft Scaffolding? ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    42. Laminin-511 Is an Epithelial Message Promoting Dermal Papilla Development and Function During Early Hair Morphogenesis Genes & Development · 2008
    43. Enhanced Ectodysplasin-A Receptor Signaling Alters Multiple Fiber Characteristics to Produce the East Asian Hair Form Human mutation · 2008
    44. Beyond Wavy Hairs: The Role of EGFR in Skin and Hair Biology American Journal Of Pathology · 2008
    45. The Human Keratins: Biology And Pathology Histochemistry and Cell Biology · 2008
    46. Epidermal Notch Signaling: Differentiation, Cancer, and Adhesion Current opinion in cell biology · 2008
    47. Disruption of P2RY5, an Orphan G Protein–Coupled Receptor, Underlies Autosomal Recessive Woolly Hair Nature genetics · 2008
    48. Stem Cell Factor/c-Kit Signaling in Normal and Androgenetic Alopecia Hair Follicles Journal of Endocrinology · 2008
    49. Building Epithelial Tissues From Skin Stem Cells Cold Spring Harbor Symposia on Quantitative Biology · 2008
    50. Frontiers in the Neuroendocrine Controls of Hair Growth Journal of Investigative Dermatology Symposium Proceedings · 2007
    51. Human Hair Keratin Network And Curvature International Journal of Dermatology · 2007
    52. Worldwide Diversity of Hair Curliness: A New Method of Assessment International Journal of Dermatology · 2007
    53. Prostaglandin Metabolism in Human Hair Follicle Experimental Dermatology · 2007
    54. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007
    55. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    56. Hair Follicle Regeneration Using Grafted Rodent and Human Cells Journal of Investigative Dermatology · 2007
    57. Novel Type I Hair Keratins K39 And K40 Are The Last To Be Expressed In Differentiation Of The Hair: Completion Of The Human Hair Keratin Catalog Journal of Investigative Dermatology · 2007
    58. Structural Changes in Trichocyte Intermediate Filaments During Transition from Reduced to Oxidized Form Journal of Structural Biology · 2007
    59. Shape Variability and Classification of Human Hair: A Worldwide Approach Human biology · 2007
    60. Order From Disorder: Self-Organization In Mammalian Hair Patterning Proceedings of the National Academy of Sciences · 2006
    61. Bone Morphogenetic Protein Signaling Regulates the Size of Hair Follicles and Modulates the Expression of Cell Cycle-Associated Genes Proceedings of the National Academy of Sciences of the United States of America · 2006
    62. Biology of the Wool Follicle: An Excursion into a Unique Tissue Interaction System Waiting to Be Rediscovered Experimental Dermatology · 2006
    63. Dynamic Expression of Runx1 in Skin Affects Hair Structure Mechanisms of Development · 2006
    64. The Hair Follicle as an Estrogen Target and Source Endocrine Reviews · 2006
    65. K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), And K28 (K25irs4) Represent The Type I Inner Root Sheath Keratins Of The Human Hair Follicle Journal of Investigative Dermatology · 2006
    66. Chemotherapy Targets the Hair Follicle Vascular Network but Not the Stem Cells Journal of Investigative Dermatology · 2006
    67. Evidence That the Satin Hair Mutant Gene Foxq1 Is Among Multiple and Functionally Diverse Regulatory Targets for Hoxc13 During Hair Follicle Differentiation Journal of biological chemistry/˜The œJournal of biological chemistry · 2006
    68. Differences in Expression of Specific Biomarkers Distinguish Human Beard from Scalp Dermal Papilla Cells Journal of Investigative Dermatology · 2006
    69. Keratin 17 Modulates Hair Follicle Cycling in a TNFα-Dependent Fashion Genes & Development · 2006
    70. Comparative Characterization of Hair Follicle Dermal Stem Cells and Bone Marrow Mesenchymal Stem Cells Stem Cells and Development · 2006
    71. Wnt Signaling Induces Epithelial Differentiation During Cutaneous Wound Healing BMC Cell Biology · 2006
    72. Human Hair Keratin-Associated Proteins International review of cytology · 2006
    73. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    74. Runx3 Is Involved in Hair Shape Determination Developmental dynamics · 2005
    75. Isolation and Characterization of Human Repetin, a Member of the Fused Gene Family of the Epidermal Differentiation Complex Journal of Investigative Dermatology · 2005
    76. Influence of Prostaglandin F2α and Its Analogues on Hair Regrowth and Follicular Melanogenesis in a Murine Model Experimental dermatology · 2005
    77. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005
    78. Hair Shaft Abnormalities: Clues to Diagnosis and Treatment Dermatology · 2005
    79. Normal Head-Hair Length Is Correlated With Its Diameter Clinical and Experimental Dermatology · 2004
    80. Comparative Aspects of the Inner Root Sheath in Adult and Developing Hairs of Mammals in Relation to the Evolution of Hairs Journal of Anatomy · 2004
    81. The Intermediate Filament Architecture as Determined by X-Ray Diffraction Modeling of Hard Alpha-Keratin Biophysical Journal · 2004
    82. Androgen Regulation of the Human Hair Follicle: The Type I Hair Keratin hHa7 Is a Direct Target Gene in Trichocytes Journal of Investigative Dermatology · 2004
    83. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    84. Hair Follicle Differentiation And Regulation The International Journal of Developmental Biology · 2004
    85. Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 21 in Fond Memory of Dr. Peter Steinert ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2004
    86. Hair Follicle Dermal Cells Differentiate Into Adipogenic and Osteogenic Lineages Experimental Dermatology · 2003
    87. Plasticity and Cytokinetic Dynamics of the Hair Follicle Mesenchyme During the Hair Growth Cycle: Implications for Growth Control and Hair Follicle Transformations ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2003
    88. Stimulation of Ectodermal Organ Development by Ectodysplasin-A1 Developmental Biology · 2003
    89. K6irs1, K6irs2, K6irs3, And K6irs4 Represent The Inner-Root-Sheath-Specific Type II Epithelial Keratins Of The Human Hair Follicle Journal of Investigative Dermatology · 2003
    90. Hair Keratin Pattern in Human Hair Follicles Grown In Vitro Experimental dermatology · 2003
    91. Steroidogenic Isoenzymes in Human Hair and Their Potential Role in Androgenetic Alopecia Dermatology · 2003
    92. Straight Hair Associated with Interferon-Alpha Plus Ribavirin in Hepatitis C Infection British Journal of Dermatology · 2002
    93. The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling ˜The œAmerican journal of pathology · 2002
    94. HOXC13 Is Involved in the Regulation of Human Hair Keratin Gene Expression Journal of Biological Chemistry · 2002
    95. Disorders of Hair in Infants and Children Other Than Alopecia Clinics in dermatology · 2002
    96. Human Follicular Papilla Cells Carry Out Non-Adipose Tissue Production of Leptin Journal of Investigative Dermatology · 2001
    97. Indications for a Brain-Hair Follicle Axis: Inhibition of Keratinocyte Proliferation and Up-Regulation of Keratinocyte Apoptosis in Telogen Hair Follicles by Stress and Substance P The FASEB Journal · 2001
    98. The Catalog of Human Hair Keratins Journal of Biological Chemistry · 2001
    99. The Transcriptional Repressor CDP (Cutl1) Is Essential for Epithelial Cell Differentiation of the Lung and the Hair Follicle Genes & development · 2001
    100. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    101. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    102. Two Distinct Signaling Pathways in Hair Cycle Induction: Stat3-Dependent and Independent Pathways Proceedings of the National Academy of Sciences of the United States of America · 2000
    103. Modeling the Dynamics of Human Hair Cycles by a Follicular Automaton Proceedings of the National Academy of Sciences · 2000
    104. Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses Journal of Investigative Dermatology · 1999
    105. Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog Journal of Clinical Investigation · 1999
    106. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    107. Manipulation of Outer Root Sheath Cell Survival Perturbs the Hair-Growth Cycle The EMBO Journal · 1999
    108. Ultrastructural Localization of S100A3, a Cysteine-Rich, Calcium Binding Protein, in Human Scalp Hair Shafts Revealed by Rapid-Freezing Immunocytochemistry Journal of Histochemistry & Cytochemistry · 1999
    109. WNT Signaling in the Control of Hair Growth and Structure Developmental biology · 1999
    110. Gene Expression of Mouse S100A3, a Cysteine-Rich Calcium-Binding Protein, in Developing Hair Follicle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    111. Angora Mouse Mutation: Altered Hair Cycle, Follicular Dystrophy, Phenotypic Maintenance of Skin Grafts, and Changes in Keratin Expression Veterinary Pathology · 1997
    112. The Role of Keratin Proteins and Their Genes in the Growth, Structure, and Properties of Hair Birkhäuser Basel eBooks · 1997
    113. Dermal-Epidermal Interactions in Hair Follicle Development and Maintenance Dermatologic clinics · 1996
    114. Growth Factors in Hair Organ Development and the Hair Growth Cycle Dermatologic Clinics · 1996
    115. The Proximal Promoter of the Human Transglutaminase 3 Gene Journal of biological chemistry/˜The œJournal of biological chemistry · 1996
    116. Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells Biochemical and biophysical research communications · 1995
    117. Ultrastructural Visualization of Cross-Linked Protein Features in Epidermal Appendages Journal of Cell Science · 1994
    118. Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1994
    119. Dynamic Expression Patterns of Tenascin, Proteoglycans, and Cell Adhesion Molecules During Human Hair Follicle Morphogenesis Developmental dynamics · 1994
    120. Melanogenesis Is Coupled to Murine Anagen: Toward New Concepts for the Role of Melanocytes and the Regulation of Melanogenesis in Hair Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993
    121. The Structure of Human Trichohyalin: Potential Multiple Roles as a Functional EF-Hand-Like Calcium-Binding Protein, a Cornified Cell Envelope Precursor, and an Intermediate Filament-Associated (Cross-Linking) Protein Journal of Biological Chemistry · 1993
    122. Telogen Effluvium: A Comprehensive Review Archives of Dermatology · 1993
    123. The Secret Life of the Hair Follicle Trends in genetics · 1992
    124. The Presence of Glycoproteins in the Cell Membrane Complex of Various Keratin Fibers Biochimica et Biophysica Acta (BBA) - General Subjects · 1991
    125. Natural Progression of Male Pattern Baldness in Young Men Clinical and Experimental Dermatology · 1991
    126. Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation The Journal of Cell Biology · 1989
    127. Hair, Wool, Quill, Nail, Claw, Hoof, and Horn 1986
    128. The Unit Area Trichogram in the Assessment of Androgen-Dependent Alopecia British Journal of Dermatology · 1983
    129. Hair Diameter in Female Baldness British Journal of Dermatology · 1972
    130. Nutritional Factors Influencing Hair and Wool Growth Elsevier eBooks · 1958