Human Follicular Papilla Cells Carry Out Non-Adipose Tissue Production of Leptin
December 2001
in “
Journal of Investigative Dermatology
”
Research cited in this study
11 / 11 resultsresearch Expression of vascular endothelial growth factor (VEGF) in various compartments of the human hair follicle
research Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice
Overexpressing IGF-1 in mice leads to skin abnormalities and tumors.
research Transgenic Mice Expressing IFN-γ in the Epidermis Have Eczema, Hair Hypopigmentation, and Hair Loss
research Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy
Growth factors and cytokines are important for hair growth and could potentially treat hair loss, but more research is needed to overcome challenges before they can be used in treatments.
research Vascular Endothelial Growth Factor Is an Autocrine Growth Factor for Hair Dermal Papilla Cells
research Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia.
The study demonstrated that keratinocyte growth factor (KGF or FGF-7) played a significant role in hair follicle growth, development, and differentiation. KGF and its receptor were highly expressed in skin, particularly in developing hair follicles. In experiments with nu/nu athymic nude mice, recombinant KGF (rKGF) induced dose-dependent hair growth and normalized follicular defects. Additionally, in a neonatal rat model of chemotherapy-induced alopecia, rKGF provided a dose-dependent protective effect, reducing alopecia by up to 50%. These findings suggested that KGF was a crucial endogenous factor in hair follicle biology.
research Human hair growth in vitro: a model for the study of hair follicle biology
research IL-1 Alpha Inhibits Human Hair Follicle Growth And Hair Fiber Production In Whole-Organ Cultures
IL-1 alpha stops hair follicle growth and hair production.
research Fibroblast Growth Factor Influences the Development and Cycling of Murine Hair Follicles
research Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice.
TNF alpha in skin cells causes weight loss, hair and fat issues, and skin inflammation in mice.
research Epidermal growth factor delays the development of the epidermis and hair follicles of mice during growth of the first coat
The study investigated the effects of epidermal growth factor (EGF) on the development of the epidermis and hair follicles in male mice during the formation of their first coat. EGF treatment from birth resulted in a temporary thickening of the epidermis and maintained high levels of cell proliferation for 8 days, delaying the normal thinning process seen in control mice. This delay in epidermal development was accompanied by inhibited hair growth and reduced hair diameter, as EGF inhibited the growth of hair follicle bulbs and the increase in bulb cell numbers during the early anagen phase. Despite these changes, the size and cell numbers of the dermal papilla were not significantly affected. Overall, EGF delayed normal skin development by maintaining active proliferative and differentiation processes, leading to inhibited follicle development and hair growth.