Concise Review: Human Dermis as an Autologous Source of Stem Cells for Tissue Engineering and Regenerative Medicine
August 2015
in “
Stem Cells Translational Medicine
”
dermal stem cells DSCs autologous cells skin regeneration hair follicle regeneration neuroregeneration hematopoietic regeneration cartilage tissue engineering neoplastic transformation stem cells patient's own cells skin repair hair growth nerve repair blood cell regeneration cartilage repair cancer risk
TLDR Human skin can provide stem cells for tissue repair and regeneration, but there are challenges in obtaining and growing these cells safely.
The 2015 document "Human Dermis as an Autologous Source of Stem Cells for Tissue Engineering and Regenerative Medicine" explored the potential of dermal stem cells (DSCs) from the human dermis for tissue engineering and regenerative medicine. The researchers highlighted the benefits of using autologous cells, which are derived from the patient's own body, reducing the risk of immune rejection. The study emphasized the multilineage potential of DSCs, including their use in skin and hair follicle regeneration, neuroregeneration, hematopoietic regeneration, and cartilage tissue engineering. However, the authors noted challenges in isolating and expanding these cells, the need for more specific characterization techniques, and safety concerns such as the risk of neoplastic transformation. Despite these challenges, the document concluded that understanding and addressing these issues could greatly improve the fields of tissue engineering and regenerative medicine.
